SYCP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYCP2_MOUSE
• UniProt AC: Q9CUU3
• Protein Name: Synaptonemal complex protein 2
• Gene Name: Sycp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1500
• Subcellular Localization: Nucleus . Chromosome . In axial/lateral elements of the tripartite segments of synaptonemal complexes.
• Protein Description: Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. [PubMed: 16717126 Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility]
• Protein Sequence: MPVRPDLQQLEKCIDDALRKNDFKPLLALLQIDICEDVKIKCSKQFLRKLDDLICRELNKKDIQTVSSILISIGRCSKNIFILGQAGLQTMIKQGLVQKMVSWFENSKEIILNQQQSKDEAVMNMIEDLFDLLMVIYDISDEGKNQVLESFIPQICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILSNQEMLTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKEIKDCEFETDCRIFLNLVNGILGDKRRVYTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDEEDHQWEAVTVPEEKVQMYNIEVRESKKLLTLTLKNIVKISKKEGKELLFYFDESLEITNVTKKVFGGNKYKEFTRKQGISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSDIQKKLVNPLELGNSSSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSREPLQAINSVEKAVSKTSESGMDYAASPKSRQSDGRKRWNNRANHNKTTAVIQNKQYEDNESPDQNFNEIEDTLSNVSSAVGKVDKPVLPGVLDISKNTTHSRWACWTPVTTIKLCNNQRSRALPGDTCTQDTGVNKKCTKQKSVSDDDSEETQKGKYSKDVIKCNKSDEAEFCERNIQEQNHPKYSQKKNTANAKKSDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSKRNHTKSRKELMSELTSCELEEIPVRENSKGKRFTGASESLINQISRRYNPSDSMMSTRKLKEPQDGSGFSKKPDLQFNKVQRKSYRKLKATVVNVTSECPLDDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSLKLVKNHDEHDPFLKTKDKRMLSYEKKTLLSDTETECGCDDSKTDISWLKEPKTKRLMDYSRNKNTTKYKSRKSRSSMEKGQPRPTMVLNKNSMKNDYEVVVDGRTRLPRRATKTKKNYKDLSTSESESESEKECSYLFKDKLPTKEETIHSRAQTKKLPEKQQKVFNSEALKGQPSEEQKNSSRLREGREDSLCLSSASVSRSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAPSPEFLNGNNSVVGRGQSPRISETSAMCVRKSYSPASGPPFSPRHTPTKNNSVVNMKKANSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPESCDNHMQNKREGNHAASPLSLSSEKIEKMWFDMPSENTHVSGPSQRGSKRRMYLEDDELSNSNEAEVEEAEEREHLLSKKRCQWENSDQHTFKTSLSTPDFSVPKDWQQELQGAGMFYDNISSDYKRKTDSQHKIMDDFTTKTLKLTQQHLMAMTSQAQGRRDENVEKFQVTLLDELEKVEKDSQTLRDLEKELVDIEEKLVQKMRAYHRCERERFRVLKTSLDKSFLVYNSVYEESVFTSEMCLMKANMKMLQDKLLKEMHEEEVLNIRRGLQSLFKAHEGNDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
425	Phosphorylation	SQILVPESQPSPVKE CEEECCCCCCCCCHH	41.12	25293948
428	Phosphorylation	LVPESQPSPVKENLI ECCCCCCCCCHHHCC	34.39	25293948
456	Phosphorylation	NPLELGNSSSQDEIT CHHHHCCCCCCCCCC	29.57	22817900
457	Phosphorylation	PLELGNSSSQDEITT HHHHCCCCCCCCCCC	35.70	22817900
458	Phosphorylation	LELGNSSSQDEITTP HHHCCCCCCCCCCCC	41.28	22817900
463	Phosphorylation	SSSQDEITTPSRKKM CCCCCCCCCCCCCCC	30.52	25293948
464	Phosphorylation	SSQDEITTPSRKKMS CCCCCCCCCCCCCCC	25.57	22817900
466	Phosphorylation	QDEITTPSRKKMSEA CCCCCCCCCCCCCCC	55.42	25293948
471	Phosphorylation	TPSRKKMSEASMIVP CCCCCCCCCCCCCCC	38.60	22817900
474	Phosphorylation	RKKMSEASMIVPDTD CCCCCCCCCCCCCCC	12.65	22817900
480	Phosphorylation	ASMIVPDTDRYTVRS CCCCCCCCCCCCCCC	19.12	22817900
483	Phosphorylation	IVPDTDRYTVRSPIL CCCCCCCCCCCCCEE	16.64	19060867
484	Phosphorylation	VPDTDRYTVRSPILL CCCCCCCCCCCCEEE	15.44	25293948
487	Phosphorylation	TDRYTVRSPILLINT CCCCCCCCCEEEEEC	16.38	22817900
494	Phosphorylation	SPILLINTSTPRRSR CCEEEEECCCCCCCC	27.30	22817900
495	Phosphorylation	PILLINTSTPRRSRE CEEEEECCCCCCCCH	31.74	25293948
496	Phosphorylation	ILLINTSTPRRSREP EEEEECCCCCCCCHH	20.83	22817900
500	Phosphorylation	NTSTPRRSREPLQAI ECCCCCCCCHHHHHH	42.13	22817900
509	Phosphorylation	EPLQAINSVEKAVSK HHHHHHHHHHHHHHH	26.07	22817900
515	Phosphorylation	NSVEKAVSKTSESGM HHHHHHHHHCCCCCC	34.77	21082442
517	Phosphorylation	VEKAVSKTSESGMDY HHHHHHHCCCCCCCC	30.16	21082442
518	Phosphorylation	EKAVSKTSESGMDYA HHHHHHCCCCCCCCC	33.24	22817900
527	Phosphorylation	SGMDYAASPKSRQSD CCCCCCCCCCCCCCC	25.37	22817900
557	Phosphorylation	AVIQNKQYEDNESPD EEEECCCCCCCCCCC	27.19	25293948
562	Phosphorylation	KQYEDNESPDQNFNE CCCCCCCCCCCCHHH	39.78	25293948
573	Phosphorylation	NFNEIEDTLSNVSSA CHHHHHHHHHHHHHH	21.21	25293948
608	Phosphorylation	HSRWACWTPVTTIKL CCCEEEECCHHHEEE	14.04	22817900
611	Phosphorylation	WACWTPVTTIKLCNN EEEECCHHHEEECCC	24.81	25293948
630	Phosphorylation	ALPGDTCTQDTGVNK CCCCCCCCCCCCCCC	31.41	19060867
633	Phosphorylation	GDTCTQDTGVNKKCT CCCCCCCCCCCCHHH	32.96	22817900
644	Phosphorylation	KKCTKQKSVSDDDSE CHHHCCCCCCCCCCH	25.10	21082442
646	Phosphorylation	CTKQKSVSDDDSEET HHCCCCCCCCCCHHH	42.27	22817900
650	Phosphorylation	KSVSDDDSEETQKGK CCCCCCCCHHHHHCC	44.31	22817900
668	Phosphorylation	DVIKCNKSDEAEFCE CCHHCCCCCHHHHHH	27.05	22817900
706	Phosphorylation	DWHIESETTYKSVLL CCCCCCCCEECEEEC	44.71	28576409
736	Phosphorylation	LSKDVNTTICDKSPS ECCCCCCCCCCCCCC	17.88	22817900
741	Phosphorylation	NTTICDKSPSRKSKR CCCCCCCCCCHHHHC	18.17	22817900
763	Phosphorylation	ELMSELTSCELEEIP HHHHHHHCCCEEECC	20.44	21183079
879	Phosphorylation	QATTREASMDNSLKL HHHCCCCCCCCCCHH	23.16	22817900
911	Phosphorylation	MLSYEKKTLLSDTET HHCCCCCCCCCCCCC	43.96	22817900
914	Phosphorylation	YEKKTLLSDTETECG CCCCCCCCCCCCCCC	45.67	22817900
916	Phosphorylation	KKTLLSDTETECGCD CCCCCCCCCCCCCCC	41.24	22817900
918	Phosphorylation	TLLSDTETECGCDDS CCCCCCCCCCCCCCC	38.37	22817900
925	Phosphorylation	TECGCDDSKTDISWL CCCCCCCCCCCCHHH	24.97	25293948
927	Phosphorylation	CGCDDSKTDISWLKE CCCCCCCCCCHHHCC	42.38	25293948
930	Phosphorylation	DDSKTDISWLKEPKT CCCCCCCHHHCCCCC	29.21	25293948
959	Phosphorylation	YKSRKSRSSMEKGQP HCCCCCHHHHCCCCC	40.92	29472430
960	Phosphorylation	KSRKSRSSMEKGQPR CCCCCHHHHCCCCCC	29.83	29472430
1006	Phosphorylation	KKNYKDLSTSESESE CCCHHCCCCCCCCCC	39.77	25293948
1007	Phosphorylation	KNYKDLSTSESESES CCHHCCCCCCCCCCC	43.76	25293948
1008	Phosphorylation	NYKDLSTSESESESE CHHCCCCCCCCCCCH	35.43	25293948
1010	Phosphorylation	KDLSTSESESESEKE HCCCCCCCCCCCHHH	46.30	25293948
1012	Phosphorylation	LSTSESESESEKECS CCCCCCCCCCHHHHH	56.56	25293948
1014	Phosphorylation	TSESESESEKECSYL CCCCCCCCHHHHHHH	64.35	25293948
1019	Phosphorylation	SESEKECSYLFKDKL CCCHHHHHHHHCCCC	26.43	25293948
1080	Phosphorylation	REDSLCLSSASVSRS CCCCCEEECCCCCCC	23.90	25293948
1081	Phosphorylation	EDSLCLSSASVSRSS CCCCEEECCCCCCCC	16.18	25293948
1083	Phosphorylation	SLCLSSASVSRSSSS CCEEECCCCCCCCCC	23.67	25293948
1085	Phosphorylation	CLSSASVSRSSSSVE EEECCCCCCCCCCCE	24.77	25293948
1106	Phosphorylation	KITERDFTQDYDYIT CHHHCCCCCCHHHHH	25.48	22817900
1111	Phosphorylation	DFTQDYDYITKSLSP CCCCCHHHHHHCCCC	12.31	21183079
1113	Phosphorylation	TQDYDYITKSLSPYP CCCHHHHHHCCCCCC	14.35	22817900
1115	Phosphorylation	DYDYITKSLSPYPKA CHHHHHHCCCCCCCC	25.98	22817900
1117	Phosphorylation	DYITKSLSPYPKAPS HHHHHCCCCCCCCCC	29.49	22817900
1119	Phosphorylation	ITKSLSPYPKAPSPE HHHCCCCCCCCCCHH	17.62	19060867
1124	Phosphorylation	SPYPKAPSPEFLNGN CCCCCCCCHHHHCCC	41.75	22817900
1133	Phosphorylation	EFLNGNNSVVGRGQS HHHCCCCCCCCCCCC	23.37	22817900
1140	Phosphorylation	SVVGRGQSPRISETS CCCCCCCCCCCCCCC	20.97	22817900
1144	Phosphorylation	RGQSPRISETSAMCV CCCCCCCCCCCEEEE	35.78	22817900
1146	Phosphorylation	QSPRISETSAMCVRK CCCCCCCCCEEEECC	18.26	22817900
1147	Phosphorylation	SPRISETSAMCVRKS CCCCCCCCEEEECCC	15.23	22817900
1154	Phosphorylation	SAMCVRKSYSPASGP CEEEECCCCCCCCCC	21.93	19060867
1155	Phosphorylation	AMCVRKSYSPASGPP EEEECCCCCCCCCCC	23.00	19060867
1156	Phosphorylation	MCVRKSYSPASGPPF EEECCCCCCCCCCCC	22.53	22817900
1159	Phosphorylation	RKSYSPASGPPFSPR CCCCCCCCCCCCCCC	56.04	22817900
1164	Phosphorylation	PASGPPFSPRHTPTK CCCCCCCCCCCCCCC	27.14	22817900
1168	Phosphorylation	PPFSPRHTPTKNNSV CCCCCCCCCCCCCCC	33.65	22817900
1170	Phosphorylation	FSPRHTPTKNNSVVN CCCCCCCCCCCCCCC	47.78	21183079
1174	Phosphorylation	HTPTKNNSVVNMKKA CCCCCCCCCCCHHHH	36.51	22817900
1183	Phosphorylation	VNMKKANSVINNQRT CCHHHHHHHHCCCCC	29.27	22817900
1213	Phosphorylation	KLYMEPESPESCDNH CEECCCCCHHHHHHH	44.69	25293948
1216	Phosphorylation	MEPESPESCDNHMQN CCCCCHHHHHHHHHC	30.10	25293948
1232	Phosphorylation	REGNHAASPLSLSSE CCCCCCCCCCCCCHH	27.45	22817900
1235	Phosphorylation	NHAASPLSLSSEKIE CCCCCCCCCCHHHHH	29.59	22817900
1237	Phosphorylation	AASPLSLSSEKIEKM CCCCCCCCHHHHHHH	32.83	22817900
1238	Phosphorylation	ASPLSLSSEKIEKMW CCCCCCCHHHHHHHH	48.48	22817900
1250	Phosphorylation	KMWFDMPSENTHVSG HHHCCCCCCCCCCCC	36.52	22817900
1253	Phosphorylation	FDMPSENTHVSGPSQ CCCCCCCCCCCCCCC	21.43	25293948
1256	Phosphorylation	PSENTHVSGPSQRGS CCCCCCCCCCCCCCC	37.06	21183079
1259	Phosphorylation	NTHVSGPSQRGSKRR CCCCCCCCCCCCCCC	35.71	22817900
1268	Phosphorylation	RGSKRRMYLEDDELS CCCCCCEEECCHHCC	12.72	28576409
1275	Phosphorylation	YLEDDELSNSNEAEV EECCHHCCCCCHHHH	35.84	22817900
1277	Phosphorylation	EDDELSNSNEAEVEE CCHHCCCCCHHHHHH	32.44	22817900
1293	Phosphorylation	EEREHLLSKKRCQWE HHHHHHHHCCCCCCC	42.35	22817900
1309	Phosphorylation	SDQHTFKTSLSTPDF CCCCCEECCCCCCCC	30.61	25293948
1310	Phosphorylation	DQHTFKTSLSTPDFS CCCCEECCCCCCCCC	22.40	25293948
1312	Phosphorylation	HTFKTSLSTPDFSVP CCEECCCCCCCCCCC	37.35	22817900
1313	Phosphorylation	TFKTSLSTPDFSVPK CEECCCCCCCCCCCH	31.97	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYCP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYCP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYCP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TEX11_MOUSE	Tex11	physical	18316482

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.