dbPTM

SVOP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SVOP_HUMAN
UniProt AC	Q8N4V2
Protein Name	Synaptic vesicle 2-related protein
Gene Name	SVOP
Organism	Homo sapiens (Human).
Sequence Length	548
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Multi-pass membrane protein.
Protein Description
Protein Sequence	MEEDLFQLRQLPVVKFRRTGESARSEDDTASGEHEVQIEGVHVGLEAVELDDGAAVPKEFANPTDDTFMVEDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQEDRGKMRDLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQESSHREWGQEMVGRGMHGAGVTRSNSGSQE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	RTGESARSEDDTASG ECCCCCCCCCCCCCC	45.13	-
31	Phosphorylation	RSEDDTASGEHEVQI CCCCCCCCCCEEEEE	46.97	-
156	Phosphorylation	RKTGLKISVLWTLYY CCCCCHHHHHHHHHH	15.01	-
160	Phosphorylation	LKISVLWTLYYGILS CHHHHHHHHHHHHHH	10.75	-
273	Ubiquitination	VLSGNQEKAIATLKR CCCCCHHHHHHHHHH	35.02	32142685
279	Ubiquitination	EKAIATLKRIATENG HHHHHHHHHHHHHCC	37.09	32142685
293	Ubiquitination	GAPMPLGKLIISRQE CCCCCCCCEEEECCH	44.17	32142685
297	Phosphorylation	PLGKLIISRQEDRGK CCCCEEEECCHHHCC	22.40	30576142
542	Phosphorylation	HGAGVTRSNSGSQE- CCCCCCCCCCCCCC-	26.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SVOP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SVOP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SVOP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SVOP_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SVOP_HUMAN

Related Literatures of Post-Translational Modification