SV2B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SV2B_RAT
• UniProt AC: Q63564
• Protein Name: Synaptic vesicle glycoprotein 2B
• Gene Name: Sv2b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 683
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, acrosome . Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secre
• Protein Description: Probably plays a role in the control of regulated secretion in neural and endocrine cells.; Receptor for the botulinium neurotoxin type A/BOTA..
• Protein Sequence: MDDYRYRDNYEGYAPNDGYYRGNEQNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKSKQTKMAPSRADGLRGQADLMAERMEDEEQLAHQYETIIDECGHGRFQWTLFFVLVLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKTPKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFIDCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKLGAILGNTIFASFVGITKVVPILLAAASLVGGGLVALRLPETREQVLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	NPEEDAQSDVTEGHD CHHHHHHCCCCCCCC	35.45	22673903
36	Phosphorylation	EDAQSDVTEGHDEED HHHHCCCCCCCCCCC	41.04	22673903
46	Phosphorylation	HDEEDEIYEGEYQGI CCCCCCHHCCCCCCC	18.81	22673903
50	Phosphorylation	DEIYEGEYQGIPHPD CCHHCCCCCCCCCHH	23.93	22673903
330	Phosphorylation	TNMRAKGTPEKVFTV HCCCCCCCCCCEEEE	27.80	25403869
341	Ubiquitination	VFTVSHIKTPKQMDE EEEEEEECCHHHHHC	54.04	-
342	Phosphorylation	FTVSHIKTPKQMDEF EEEEEECCHHHHHCC	34.81	25403869
423	Phosphorylation	RYFQDEEYKSKMKVF HHHCCHHHHHHCEEE	20.65	25403869
441	N-linked_Glycosylation	HVHGATINFTMENQI CCCCCEEEEEECCCH	23.21	-
458	Acetylation	HGKLVNDKFIKMYFK CCCCCCHHHHHHHHH	43.73	22902405
491	N-linked_Glycosylation	STDTYFKNCTIESTT CCCCEECCCEEEEEE	20.47	-
516	N-linked_Glycosylation	FIDCRFINSTFLEQK EEEEEECCCHHHHCC	32.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SV2B_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SV2B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SV2B_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SV2B_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.