SV2A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SV2A_RAT
• UniProt AC: Q02563
• Protein Name: Synaptic vesicle glycoprotein 2A
• Gene Name: Sv2a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 742
• Subcellular Localization: Cell junction, synapse . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like mic
• Protein Description: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.; Receptor for the botulinium neurotoxin type A/BOTA..
• Protein Sequence: MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEEDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	QDEYSRRSYSRFEEE HHHHHHHHHHCCCCC	26.75	22673903
46	Phosphorylation	DEYSRRSYSRFEEEE HHHHHHHHHCCCCCC	11.31	22673903
47	Phosphorylation	EYSRRSYSRFEEEED HHHHHHHHCCCCCCC	31.57	22673903
48	Methylation	YSRRSYSRFEEEEDD HHHHHHHCCCCCCCC	34.46	4199045
65	Phosphorylation	FPAPADGYYRGEGAQ CCCCCCCCCCCCCCC	7.19	22673903
66	Phosphorylation	PAPADGYYRGEGAQD CCCCCCCCCCCCCCC	20.05	22673903
80	Phosphorylation	DEEEGGASSDATEGH CCCCCCCCCCCCCCC	31.83	30411139
81	Phosphorylation	EEEGGASSDATEGHD CCCCCCCCCCCCCCC	30.63	30411139
84	Phosphorylation	GGASSDATEGHDEDD CCCCCCCCCCCCCCC	47.71	30411139
94	Phosphorylation	HDEDDEIYEGEYQGI CCCCCCCCCCCCCCC	18.81	22673903
98	Phosphorylation	DEIYEGEYQGIPRAE CCCCCCCCCCCCCCC	23.93	22673903
106	Phosphorylation	QGIPRAESGGKGERM CCCCCCCCCCCCCCC	52.43	28551015
127	Phosphorylation	AGVRGGLSDGEGPPG CCCCCCCCCCCCCCC	47.01	30411139
143	Ubiquitination	RGEAQRRKDREELAQ CCHHHHHHHHHHHHH	64.42	-
393	Phosphorylation	GHPERVFSVTHIKTI CCHHHEEEEEEEEEE	24.21	30240740
395	Phosphorylation	PERVFSVTHIKTIHQ HHHEEEEEEEEEECC	19.38	25403869
480	Phosphorylation	RHLQAVDYAARTKVF HHHHHHHHHHHCCCC	8.79	-
498	N-linked_Glycosylation	RVEHVTFNFTLENQI CEEEEEEEEEECCCH	21.45	18815274
515	Acetylation	GGQYFNDKFIGLRLK CCCCCCCCCCEEEEE	39.73	22902405
548	N-linked_Glycosylation	SSNTFFRNCTFINTV CCCCEECCCEEEEEE	24.83	18815274
573	N-linked_Glycosylation	FVNSRLVNSTFLHNK EECCCCCCCCCCCCC	39.67	18815274

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SV2A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SV2A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SV2A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SV2A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.