SUS1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUS1_SCHPO
• UniProt AC: Q7LL15
• Protein Name: Transcription and mRNA export factor sus1 {ECO:0000255|HAMAP-Rule:MF_03046}
• Gene Name: sus1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 108
• Subcellular Localization: Nucleus, nucleoplasm . Nucleus, nuclear pore complex . Cytoplasm, P-body .
• Protein Description: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity)..
• Protein Sequence: MYDLIFSTKMTTEKIVEQLYETGDYERLANELEYKLESCGWTTQLRDYTRGIVNSDSKIDFQKLYESALQSATESIPDSVKMDLLKDIKTCVLKLANPPESANGGNKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	YTRGIVNSDSKIDFQ HHCCCCCCCCCCCHH	32.16	25720772
57	Phosphorylation	RGIVNSDSKIDFQKL CCCCCCCCCCCHHHH	31.19	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUS1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUS1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUS1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of SUS1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.