SUMO2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUMO2_RAT
• UniProt AC: P61959
• Protein Name: Small ubiquitin-related modifier 2
• Gene Name: Sumo2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 95
• Subcellular Localization: Nucleus. Nucleus, PML body.
• Protein Description: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity)..
• Protein Sequence: MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MADEKPKEGVKT ---CCCCCCCCCCCC	63.03	22902405
7	Acetylation	-MADEKPKEGVKTEN -CCCCCCCCCCCCCC	77.49	22902405
11	Acetylation	EKPKEGVKTENNDHI CCCCCCCCCCCCCCE	62.06	22902405
11	Ubiquitination	EKPKEGVKTENNDHI CCCCCCCCCCCCCCE	62.06	-
28	Phosphorylation	KVAGQDGSVVQFKIK EECCCCCCEEEEEEE	27.66	23984901
33	Acetylation	DGSVVQFKIKRHTPL CCCEEEEEEEECCHH	30.17	22902405
42	Acetylation	KRHTPLSKLMKAYCE EECCHHHHHHHHHHH	61.35	22902405
42	Ubiquitination	KRHTPLSKLMKAYCE EECCHHHHHHHHHHH	61.35	-
45	Acetylation	TPLSKLMKAYCERQG CHHHHHHHHHHHHCC	46.79	22902405
45	Ubiquitination	TPLSKLMKAYCERQG CHHHHHHHHHHHHCC	46.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUMO2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
6	K	ubiquitylation	Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 (By similarity).	-
11	K	ubiquitylation	Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 (By similarity).	-
48	K	ubiquitylation	Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUMO2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SUMO2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.