SUCA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUCA_RAT
• UniProt AC: P13086
• Protein Name: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03222}
• Gene Name: Suclg1 {ECO:0000255|HAMAP-Rule:MF_03222}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 346
• Subcellular Localization: Mitochondrion .
• Protein Description: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits..
• Protein Sequence: MTAAVVAAAATATMVSGSSGLAAARLLSRTFLLQQNGIRHGSYTASRKNIYIDKNTKVICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGKKHLGLPVFNTVKEAKEKTGATASVIYVPPPFAAAAINEAIDAEIPLVVCITEGIPQQDMVRVKHKLTRQGKTRLIGPNCPGIINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCIGIGGDPFNGTNFIDCLDVFLKDPATEGIVLIGEIGGHAEENAAEFLKEHNSGPKAKPVVSFIAGITAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVIVSMSPAQLGTCMYKEFEKRKML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	AVVAAAATATMVSGS HHHHHHHHHHHHCCC	20.24	26022182
48	Acetylation	GSYTASRKNIYIDKN CCEECCCCEEEEECC	45.24	22902405
48	Succinylation	GSYTASRKNIYIDKN CCEECCCCEEEEECC	45.24	26843850
54	Acetylation	RKNIYIDKNTKVICQ CCEEEEECCCEEEEC	57.89	22902405
54	Succinylation	RKNIYIDKNTKVICQ CCEEEEECCCEEEEC	57.89	26843850
57	Acetylation	IYIDKNTKVICQGFT EEEECCCEEEECCCC	38.71	22902405
57	Succinylation	IYIDKNTKVICQGFT EEEECCCEEEECCCC	38.71	-
57	Succinylation	IYIDKNTKVICQGFT EEEECCCEEEECCCC	38.71	-
66	Acetylation	ICQGFTGKQGTFHSQ EECCCCCCCCEECHH	42.36	22902405
66	Succinylation	ICQGFTGKQGTFHSQ EECCCCCCCCEECHH	42.36	-
66	Succinylation	ICQGFTGKQGTFHSQ EECCCCCCCCEECHH	42.36	-
81	Acetylation	QALEYGTKLVGGTTP HHHHHCCEEECCCCC	36.49	22902405
86	Phosphorylation	GTKLVGGTTPGKGGK CCEEECCCCCCCCCC	24.72	28432305
87	Phosphorylation	TKLVGGTTPGKGGKK CEEECCCCCCCCCCC	33.06	28432305
90	Acetylation	VGGTTPGKGGKKHLG ECCCCCCCCCCCCCC	66.74	22902405
94	Acetylation	TPGKGGKKHLGLPVF CCCCCCCCCCCCCCC	47.54	-
103	Phosphorylation	LGLPVFNTVKEAKEK CCCCCCCCHHHHHHH	22.84	23984901
105	Acetylation	LPVFNTVKEAKEKTG CCCCCCHHHHHHHHC	50.33	22902405
108	Acetylation	FNTVKEAKEKTGATA CCCHHHHHHHHCCEE	61.92	22902405
156	Acetylation	QQDMVRVKHKLTRQG HHHHHHHHEEHHHCC	25.18	22902405
192	Acetylation	IMPGHIHKKGRIGIV ECCCCCCCCCCEEEE	57.21	22902405
271	Acetylation	ENAAEFLKEHNSGPK HHHHHHHHHCCCCCC	63.35	22902405
278	Acetylation	KEHNSGPKAKPVVSF HHCCCCCCCCCCEEE	72.99	26302492
338	Succinylation	QLGTCMYKEFEKRKM HHCCHHHHHHHHHHC	29.10	-
338	Succinylation	QLGTCMYKEFEKRKM HHCCHHHHHHHHHHC	29.10	-
342	Acetylation	CMYKEFEKRKML--- HHHHHHHHHHCC---	63.74	41680817

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUCA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUCA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUCA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SUCA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.