dbPTM

STX8_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STX8_RAT
UniProt AC	Q9Z2Q7
Protein Name	Syntaxin-8
Gene Name	Stx8
Organism	Rattus norvegicus (Rat).
Sequence Length	236
Subcellular Localization	Membrane Single-pass type IV membrane protein. Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits.
Protein Description	Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER..
Protein Sequence	MAPDPWFSTYDSTCQIAQEIAEKIQERNQCERRGEKTPKLTLTIRTLLKNLKVKIDLLKDLLLRAVSTRQITQLEGDRRQNLLDDLVTRERLLLASFKNEGSEPDLIRSSLMSEEAKRGTPNPWLCEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRTEARRVTLVDRKSASCGMIMVILLLLVAIVVVAVWPTN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Acetylation	LTIRTLLKNLKVKID HHHHHHHHHCCHHHH	64.45	22902405
96	Phosphorylation	RERLLLASFKNEGSE HHHHHHHHHCCCCCC	36.40	25575281
98	Acetylation	RLLLASFKNEGSEPD HHHHHHHCCCCCCHH	52.15	22902405
98	Ubiquitination	RLLLASFKNEGSEPD HHHHHHHCCCCCCHH	52.15	-
102	Phosphorylation	ASFKNEGSEPDLIRS HHHCCCCCCHHHHHH	39.51	29779826
120	Phosphorylation	SEEAKRGTPNPWLCE CHHHHCCCCCCCCCC	24.75	25575281
159	Phosphorylation	DAGLDALSSIISRQK HHHHHHHHHHHHHHH	22.63	28432305
160	Phosphorylation	AGLDALSSIISRQKQ HHHHHHHHHHHHHHH	25.45	28432305
163	Phosphorylation	DALSSIISRQKQMGQ HHHHHHHHHHHHHHH	27.30	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STX8_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STX8_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STX8_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of STX8_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STX8_RAT

Related Literatures of Post-Translational Modification