STX7_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX7_RAT
• UniProt AC: O70257
• Protein Name: Syntaxin-7
• Gene Name: Stx7
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 261
• Subcellular Localization: Early endosome membrane; Single-pass type IV membrane protein.
• Protein Description: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity)..
• Protein Sequence: MSYTPGIGGDPAQLAQRISSNIQKITQCSAEIQRTLNQLGTPQDTPELRQQLQQEQQYTNQLAKETDKYIKEFGFLPTTPSEQRQRKIQKDRLVAEFTTALTNFQKVQRQAAEREKEFVARVRASSRVSGGFPEDSSKEKNFVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVESAEVHVQQANQQLSRAANYQRKSRKTLCIIILILVVGIVIIFFIVWGLKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSYTPGIGG ------CCCCCCCCC	37.40	-
2	Phosphorylation	------MSYTPGIGG ------CCCCCCCCC	37.40	23984901
3	Phosphorylation	-----MSYTPGIGGD -----CCCCCCCCCC	18.69	23984901
4	Phosphorylation	----MSYTPGIGGDP ----CCCCCCCCCCH	14.03	23984901
41	Phosphorylation	RTLNQLGTPQDTPEL HHHHHCCCCCCCHHH	26.77	30240740
64	Ubiquitination	QYTNQLAKETDKYIK HHHHHHHHHHHHHHH	70.51	-
68	Acetylation	QLAKETDKYIKEFGF HHHHHHHHHHHHHCC	57.19	22902405
78	Phosphorylation	KEFGFLPTTPSEQRQ HHHCCCCCCHHHHHH	54.19	27097102
79	Phosphorylation	EFGFLPTTPSEQRQR HHCCCCCCHHHHHHH	23.91	28689409
81	Phosphorylation	GFLPTTPSEQRQRKI CCCCCCHHHHHHHHH	44.24	27097102
125	Phosphorylation	FVARVRASSRVSGGF HHHHHHHHHCCCCCC	14.23	22108457
126	Phosphorylation	VARVRASSRVSGGFP HHHHHHHHCCCCCCC	35.40	22108457
129	Phosphorylation	VRASSRVSGGFPEDS HHHHHCCCCCCCCCC	31.89	23712012
136	Phosphorylation	SGGFPEDSSKEKNFV CCCCCCCCCCCCCCC	41.47	25575281
137	Phosphorylation	GGFPEDSSKEKNFVS CCCCCCCCCCCCCCC	58.10	28689409
173	Phosphorylation	RLIHERESSIRQLEA HHHHHHHHHHHHHHH	36.97	30240740
205	Phosphorylation	EQGDVIDSIEANVES CCCCHHHHHHHHHHH	15.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STX7_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX7_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX7_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of STX7_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.