STX12_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX12_RAT
• UniProt AC: G3V7P1
• Protein Name: Syntaxin-12
• Gene Name: Stx12
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 274
• Subcellular Localization: Endosome membrane; Single-pass type IV membrane protein . Golgi apparatus membrane; Single-pass type IV membrane protein . Endomembrane system ; Single-pass type IV membrane protein ; Cytoplasmic side . Early endosome membrane ; Single-pass type IV membra
• Protein Description: SNARE that acts to regulate protein transport between endosomes and the trans-Golgi network (By similarity). The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. [PubMed: 16037816]
• Protein Sequence: MSYGPLDMYRNPGPSGPQPRDFNSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQFQHSTNQLAKETNELLKELGSLPLPLSASEQRQQKLQKERLMNDFSSALNNFQVVQRKVSEKEKESIARARAGSRLSAEDRQREEQLVSFDSHEEWNQMQSQEEEAAITEQDLELIKERETAIQQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERASDQLQRAAYYQKKSRKKMCILVLVLSVIVTVLVVVIWVASK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSYGPLDMY ------CCCCCCCCC	38.50	-
44	Acetylation	SQATAQIKNLMSQLG HHHHHHHHHHHHHHC	31.76	72620837
139	Phosphorylation	IARARAGSRLSAEDR HHHHHHHCCCCHHHH	29.12	29779826
142	Phosphorylation	ARAGSRLSAEDRQRE HHHHCCCCHHHHHHH	28.62	16396499
218	Phosphorylation	DQGDLIDSIEANVES CCCCHHHHHHHHCCC	18.48	-
225	Phosphorylation	SIEANVESSEVHVER HHHHHCCCCCHHHHH	27.76	-
234	Phosphorylation	EVHVERASDQLQRAA CHHHHHHHHHHHHHH	31.91	25403869
246	Ubiquitination	RAAYYQKKSRKKMCI HHHHHHHHHHHHHHH	39.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STX12_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX12_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX12_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of STX12_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.