STRA6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STRA6_HUMAN
• UniProt AC: Q9BX79
• Protein Name: Receptor for retinol uptake STRA6
• Gene Name: STRA6
• Organism: Homo sapiens (Human).
• Sequence Length: 667
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . In the retinal pigment epithelium localizes to the basolateral membrane.
• Protein Description: Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. [PubMed: 9452451]
• Protein Sequence: MSSQPAGNQTSPGATEDYSYGSWYIDEPQGGEELQPEGEVPSCHTSIPPGLYHACLASLSILVLLLLAMLVRRRQLWPDCVRGRPGLPSPVDFLAGDRPRAVPAAVFMVLLSSLCLLLPDEDALPFLTLASAPSQDGKTEAPRGAWKILGLFYYAALYYPLAACATAGHTAAHLLGSTLSWAHLGVQVWQRAECPQVPKIYKYYSLLASLPLLLGLGFLSLWYPVQLVRSFSRRTGAGSKGLQSSYSEEYLRNLLCRKKLGSSYHTSKHGFLSWARVCLRHCIYTPQPGFHLPLKLVLSATLTGTAIYQVALLLLVGVVPTIQKVRAGVTTDVSYLLAGFGIVLSEDKQEVVELVKHHLWALEVCYISALVLSCLLTFLVLMRSLVTHRTNLRALHRGAALDLSPLHRSPHPSRQAIFCWMSFSAYQTAFICLGLLVQQIIFFLGTTALAFLVLMPVLHGRNLLLFRSLESSWPFWLTLALAVILQNMAAHWVFLETHDGHPQLTNRRVLYAATFLLFPLNVLVGAMVATWRVLLSALYNAIHLGQMDLSLLPPRAATLDPGYYTYRNFLKIEVSQSHPAMTAFCSLLLQAQSLLPRTMAAPQDSLRPGEEDEGMQLLQTKDSMAKGARPGASRGRARWGLAYTLLHNPTLQVFRKTALLGANGAQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	N-linked_Glycosylation	MSSQPAGNQTSPGAT CCCCCCCCCCCCCCC	44.02	UniProtKB CARBOHYD
89	Phosphorylation	RGRPGLPSPVDFLAG CCCCCCCCCCHHHCC	42.47	-
231 (in isoform 3)	Ubiquitination	-	4.64	-
232	Phosphorylation	VQLVRSFSRRTGAGS HHHHHHHHCCCCCCC	23.31	17081983
244	Phosphorylation	AGSKGLQSSYSEEYL CCCCCCCCCCCHHHH	35.96	27732954
245	Phosphorylation	GSKGLQSSYSEEYLR CCCCCCCCCCHHHHH	21.51	28450419
246	Phosphorylation	SKGLQSSYSEEYLRN CCCCCCCCCHHHHHH	25.91	28450419
247	Phosphorylation	KGLQSSYSEEYLRNL CCCCCCCCHHHHHHH	26.37	19664994
250	Phosphorylation	QSSYSEEYLRNLLCR CCCCCHHHHHHHHHH	13.60	-
259 (in isoform 3)	Ubiquitination	-	38.43	-
262	Phosphorylation	LCRKKLGSSYHTSKH HHHHHHCCCCCCCCC	37.85	28857561
263	Phosphorylation	CRKKLGSSYHTSKHG HHHHHCCCCCCCCCC	21.09	28857561
264	Phosphorylation	RKKLGSSYHTSKHGF HHHHCCCCCCCCCCH	15.71	27732954
286	Phosphorylation	LRHCIYTPQPGFHLP HHHHHCCCCCCCCCC	22.77	27251275
404	Phosphorylation	RGAALDLSPLHRSPH CCCCCCCCCCCCCCC	25.69	29978859
409	Phosphorylation	DLSPLHRSPHPSRQA CCCCCCCCCCCCHHH	19.47	21712546
564	Phosphorylation	ATLDPGYYTYRNFLK CCCCCCCCHHHCCEE	11.83	-
565	Phosphorylation	TLDPGYYTYRNFLKI CCCCCCCHHHCCEEE	13.92	-
575	Phosphorylation	NFLKIEVSQSHPAMT CCEEEEECCCCHHHH	17.11	-
582	Phosphorylation	SQSHPAMTAFCSLLL CCCCHHHHHHHHHHH	20.77	-
598	Phosphorylation	AQSLLPRTMAAPQDS HHHHHHHHCCCCCCC	14.82	24173317
605	Phosphorylation	TMAAPQDSLRPGEED HCCCCCCCCCCCCCC	22.49	28857561
612 (in isoform 3)	Ubiquitination	-	54.14	-
617 (in isoform 3)	Ubiquitination	-	2.58	-
621	Ubiquitination	GMQLLQTKDSMAKGA HHHHHHHHHHHHCCC	34.54	-
643	Phosphorylation	RARWGLAYTLLHNPT HHHHHHHHHHHHCCH	11.72	19112531
644	Phosphorylation	ARWGLAYTLLHNPTL HHHHHHHHHHHCCHH	19.75	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STRA6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STRA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STRA6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of STRA6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H01027: Anophthalmia and microphthalmia (A/M)
• OMIM Disease
• 601186: Microphthalmia, syndromic, 9 (MCOPS9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.