STR3N_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STR3N_HUMAN
• UniProt AC: O95772
• Protein Name: STARD3 N-terminal-like protein {ECO:0000303|PubMed:24105263}
• Gene Name: STARD3NL {ECO:0000303|PubMed:24105263, ECO:0000312|HGNC:HGNC:19169}
• Organism: Homo sapiens (Human).
• Sequence Length: 234
• Subcellular Localization: Late endosome membrane ; Multi-pass membrane protein . Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA and VAPB.
• Protein Description: Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB. [PubMed: 24105263]
• Protein Sequence: MNHLPEDMENALTGSQSSHASLRNIHSINPTQLMARIESYEGREKKGISDVRRTFCLFVTFDLLFVTLLWIIELNVNGGIENTLEKEVMQYDYYSSYFDIFLLAVFRFKVLILAYAVCRLRHWWAIALTTAVTSAFLLAKVILSKLFSQGAFGYVLPIISFILAWIETWFLDFKVLPQEAEEENRLLIVQDASERAALIPGGLSDGQFYSPPESEAGSEEAEEKQDSEKPLLEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNHLPEDM -------CCCCCHHH		20068231
10 (in isoform 2)	Phosphorylation	-		22210691
11 (in isoform 2)	Phosphorylation	-		22210691
13	Phosphorylation	EDMENALTGSQSSHA HHHHHHHHCCCCCCH		29255136
14 (in isoform 2)	Phosphorylation	-		27135362
15	Phosphorylation	MENALTGSQSSHASL HHHHHHCCCCCCHHH		29255136
17	Phosphorylation	NALTGSQSSHASLRN HHHHCCCCCCHHHCC		29255136
18	Phosphorylation	ALTGSQSSHASLRNI HHHCCCCCCHHHCCH		29255136
21	Phosphorylation	GSQSSHASLRNIHSI CCCCCCHHHCCHHHC		29255136
27	Phosphorylation	ASLRNIHSINPTQLM HHHCCHHHCCHHHHH		30266825
31	Phosphorylation	NIHSINPTQLMARIE CHHHCCHHHHHHHHH		23090842
39	Phosphorylation	QLMARIESYEGREKK HHHHHHHHHCCCHHC		23401153
40	Phosphorylation	LMARIESYEGREKKG HHHHHHHHCCCHHCC		23403867
46	Acetylation	SYEGREKKGISDVRR HHCCCHHCCCCHHHH		7825013
193	Phosphorylation	LLIVQDASERAALIP EEEEECHHHHHHCCC		19664994
204	Phosphorylation	ALIPGGLSDGQFYSP HCCCCCCCCCCCCCC		25159151
209	Phosphorylation	GLSDGQFYSPPESEA CCCCCCCCCCCCCCC		22115753
210	Phosphorylation	LSDGQFYSPPESEAG CCCCCCCCCCCCCCC		26503892
214	Phosphorylation	QFYSPPESEAGSEEA CCCCCCCCCCCCHHH		26503892
218	Phosphorylation	PPESEAGSEEAEEKQ CCCCCCCCHHHHHHH		26503892
222 (in isoform 2)	Ubiquitination	-		21906983
227	Phosphorylation	EAEEKQDSEKPLLEL HHHHHHHCCCCCCCC		25850435
229	Ubiquitination	EEKQDSEKPLLEL-- HHHHHCCCCCCCC--		-
229	Ubiquitination	EEKQDSEKPLLEL-- HHHHHCCCCCCCC--		21906983
229 (in isoform 1)	Ubiquitination	-		21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STR3N_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STR3N_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STR3N_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.