dbPTM

STR1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STR1_SCHPO
UniProt AC	O74395
Protein Name	Siderophore iron transporter 1
Gene Name	str1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	612
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Involved in the transport of siderophore iron and so has a role in iron homeostasis..
Protein Sequence	MRLKSFSTTLDTLRRRFNDSSSEEDKLEKNIQDETSIKEVSLQDAKQSDEKGVEEKVFNDESFSIDVAPKPEDELSGIVKARYLTEHSSRISFYICYFSIFLLFFAISFQAECYYSLTAYATSAFAGHSLLSTIAVANNIISAAIKPPLARLSDVFGRLEAFLFSLLLYLVGLILMAASTNVQTYAGGSVLYNAGYTGVELIMTIFMADTSSMANRSLVLGISYLPFVVTIWIGPRVAQEFYMHSTWRWGIAVWTILIPACSIPFLAVYSYYQFRAWREGALKGTLTINPVELFKKLDIIGLILMTAGLALVLLSISLASYDTGKWSDAKFIVMIIIGGLCLIAFVLYEIFVASFPALPFRLMREPTIGACCAMSFLFYITFYCWDNYYYSFLQVVHYTSITAAGYISYTYSFTSCATGFFLGILIRLTKRYKWYFVASIPVYILGQGLMIRYRGEQYNWGYQIMPQIIVGIGGGVIANLLTVAVQTVVSTENFAIVTALVSTVTPIGGAVGSAISGAIWNSVMPKRLEKNLPSDLKDQAYTIFESLTVQLSYTRGTDARNAIILSYSEVQKILTSVATGFAGAMIFPVWFVANPRLSTVKTHIFDSKESKV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRLKSFSTTLDT ---CCCCCHHHHHHH	29.08	28889911
7	Phosphorylation	-MRLKSFSTTLDTLR -CCCCCHHHHHHHHH	27.81	29996109
8	Phosphorylation	MRLKSFSTTLDTLRR CCCCCHHHHHHHHHH	29.39	25720772
20	Phosphorylation	LRRRFNDSSSEEDKL HHHHHCCCCCHHHHH	36.55	25720772
21	Phosphorylation	RRRFNDSSSEEDKLE HHHHCCCCCHHHHHH	44.63	28889911
22	Phosphorylation	RRFNDSSSEEDKLEK HHHCCCCCHHHHHHH	49.29	28889911
35	Phosphorylation	EKNIQDETSIKEVSL HHHCCCHHHCEEEEH	44.00	29996109
36	Phosphorylation	KNIQDETSIKEVSLQ HHCCCHHHCEEEEHH	29.61	28889911
41	Phosphorylation	ETSIKEVSLQDAKQS HHHCEEEEHHHHHHC	22.77	28889911
48	Phosphorylation	SLQDAKQSDEKGVEE EHHHHHHCCCCCCCE	47.21	28889911
62	Phosphorylation	EKVFNDESFSIDVAP EECCCCCCCEEEECC	27.45	24763107
64	Phosphorylation	VFNDESFSIDVAPKP CCCCCCCEEEECCCC	27.45	28889911
607	Phosphorylation	VKTHIFDSKESKV-- CCCCCCCCCCCCC--	27.81	24763107
610	Phosphorylation	HIFDSKESKV----- CCCCCCCCCC-----	42.32	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STR1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STR1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STR1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of STR1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STR1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-21; SER-22;SER-36 AND SER-41, AND MASS SPECTROMETRY.	18257517 [Abstract]