STPG4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STPG4_HUMAN
• UniProt AC: Q8N801
• Protein Name: Protein STPG4 {ECO:0000305}
• Gene Name: STPG4 {ECO:0000312|HGNC:HGNC:26850}
• Organism: Homo sapiens (Human).
• Sequence Length: 248
• Subcellular Localization: Cytoplasm . Nucleus . Localizes in female and male zygote pronucleus. Associates preferentially with the paternal chromatin during zygote development.
• Protein Description: Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC)..
• Protein Sequence: MDQPAVATASTSIREDLVGGESFITASKPAQKTSSFEREGWWRIALTDTPIPGTYHLKTFIEESLLNPVIATYNFKNEGRKKPPLVQRNNPVLNDLPQYMPPDFLDLLKKQVATYSFKDKPRPSPSTLVDKDQSLQLSPGQYNVLPAPVPKYASRSCVFRSTVQRFPTTYFIPHEGPGPGHYNVKMPPTSSVTSCFQSRVPRFLPSCSKTPGPGAYTTLRQFPKQSPTIAKMGQEHSLFFNNNNWLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	EDLVGGESFITASKP HHHCCCCCEEECCCC		25693802
25	Phosphorylation	VGGESFITASKPAQK CCCCCEEECCCCCCC		25693802
27	Phosphorylation	GESFITASKPAQKTS CCCEEECCCCCCCCC		25693802
54	Phosphorylation	TDTPIPGTYHLKTFI ECCCCCCCEEHHHHH		22210691
55	Phosphorylation	DTPIPGTYHLKTFIE CCCCCCCEEHHHHHH		22210691
124	Phosphorylation	FKDKPRPSPSTLVDK CCCCCCCCCCCCCCC		30622161
126	Phosphorylation	DKPRPSPSTLVDKDQ CCCCCCCCCCCCCCC		30622161
127	Phosphorylation	KPRPSPSTLVDKDQS CCCCCCCCCCCCCCC		30622161
210	Phosphorylation	FLPSCSKTPGPGAYT CCCCCCCCCCCCHHC		24719451
226	Phosphorylation	LRQFPKQSPTIAKMG HHHCCCCCCCCCCCC		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STPG4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STPG4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STPG4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of STPG4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.