STPAP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STPAP_RAT
• UniProt AC: Q3MHT4
• Protein Name: Speckle targeted PIP5K1A-regulated poly(A) polymerase
• Gene Name: Tut1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 866
• Subcellular Localization: Nucleus, nucleolus . Nucleus speckle .
• Protein Description: Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation (By similarity)..
• Protein Sequence: MAAVDSDVVSLPRGRFRCCLCDVTTANRPSLDAHLKGRKHRDLVQLRATRKAQGLRSVFVSGFPRDVGSAQLSEYFQTFGPVANIVMDKDKGVFAIVEMGDISAREAVLSQPKHSLGGHTLRVRPREQKEFQSPASKSPKGVDSNSHQLAQALAEAADVGAQMVKLVELRELSEAERQLRTLVVALMQEVFTEFFPGCVVHPFGSSVNSFDVHGCDLDLFLDLGDMEEPQPDPQTPKLPEASSLDSTLASSLDPQVLACTPASLDSLSPTSLQDSEALDFETPSSLAPQTPDSALGSDTVTSPQSLPPVSPLEEDRGEGKHRKELELAEASKDEKEEATAVLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDISLSNRLALYNSRFLNLCSEMDSRVRPLVYTLRCWAQHNGLSGGGPLLNNYALTLLVIYFLQTRDPPVLPTVAQLTQRSGEGEQVEVDGWDCSFPKDASRLEPSTNVEPLSSLLAQFFSCVSCWDLSGSLLSLREGQALMVAGGLPSDLWEGLRLGPMNLQDPFDLSHNVAANVTSRVAKRLQSSCGAAASYCRSLQYQQRSSRGRDWGLLPLLQPSSPSSLLSAKLIPLPSAPFPQIITALVSVLREALGCHIEQGTKRRRSEGARSKDSPLGGANKRPRLSGQEKSCEEGKEEPQGCAGDHSENEVEEMVIELRETPQDWALLHCGPPGELPLMTAKCLDKTAEQNPMEPEGAGEGSPGETEKEASHPSSVSWRCALWHQIWQGRRRARRRFQQQTKEEGRGGPSTGAEWLAVEARVTQELKGPKSEQQRLQGEPLLTFVASASQAEQTLTVAPLQDPQGLFPGLHHFLQVFIPQALKNLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AVDSDVVSLPRGRFR CCCCCCCCCCCCCEE	32.29	23984901
392	Phosphorylation	LSNRLALYNSRFLNL HHHHHHHHCHHHHHH	12.89	-
599	Phosphorylation	LLPLLQPSSPSSLLS CCCCCCCCCHHHHHC	41.75	23984901
600	Phosphorylation	LPLLQPSSPSSLLSA CCCCCCCCHHHHHCC	35.17	23984901
602	Phosphorylation	LLQPSSPSSLLSAKL CCCCCCHHHHHCCEE	35.25	23984901
603	Phosphorylation	LQPSSPSSLLSAKLI CCCCCHHHHHCCEEE	36.39	23984901
606	Phosphorylation	SSPSSLLSAKLIPLP CCHHHHHCCEEECCC	28.75	23984901
650	Phosphorylation	RRSEGARSKDSPLGG CCCCCCCCCCCCCCC	40.04	22673903
651	Ubiquitination	RSEGARSKDSPLGGA CCCCCCCCCCCCCCC	57.58	-
653	Phosphorylation	EGARSKDSPLGGANK CCCCCCCCCCCCCCC	26.26	23298284
686	Phosphorylation	QGCAGDHSENEVEEM CCCCCCCCCCCHHHH	47.02	23298284
726	Phosphorylation	TAKCLDKTAEQNPME HHHHHHHCHHHCCCC	34.78	25575281
741	Phosphorylation	PEGAGEGSPGETEKE CCCCCCCCCCCCCHH	25.98	23298284
745	Phosphorylation	GEGSPGETEKEASHP CCCCCCCCCHHCCCC	59.27	28432305
750	Phosphorylation	GETEKEASHPSSVSW CCCCHHCCCCCCHHH	36.70	25575281
753	Phosphorylation	EKEASHPSSVSWRCA CHHCCCCCCHHHHHH	37.64	25575281
754	Phosphorylation	KEASHPSSVSWRCAL HHCCCCCCHHHHHHH	25.31	25575281
756	Phosphorylation	ASHPSSVSWRCALWH CCCCCCHHHHHHHHH	15.68	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STPAP_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STPAP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STPAP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of STPAP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.