STMN1_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STMN1_CHICK
• UniProt AC: P31395
• Protein Name: Stathmin
• Gene Name: STMN1
• Organism: Gallus gallus (Chicken).
• Sequence Length: 148
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity)..
• Protein Sequence: MATSDIQVKELEKRASGQAFELILGPRSKEAAPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKEGKDPGEAETN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KELEKRASGQAFELI HHHHHHHCCCCCHHH	35.16	-
38	Phosphorylation	AAPEFPLSPPKKKDL CCCCCCCCCCCCCCC	39.12	23106611
63	Phosphorylation	AAEERRKSHEAEVLK HHHHHHHHHHHHHHH	25.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
16	S	Phosphorylation	Kinase	PKA	-	Uniprot
38	S	Phosphorylation	Kinase	CDK1	P13863	Uniprot
38	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
63	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STMN1_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STMN1_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCMA1_CHICK	KCNMA1	physical	22174833

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.