STML2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STML2_RAT
• UniProt AC: Q4FZT0
• Protein Name: Stomatin-like protein 2, mitochondrial
• Gene Name: Stoml2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 353
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Mitochondrion . Mitochondrion inner membrane ; Lipid-anchor . Mitochondrion intermembrane space . Membrane raft . Cytoplasm, cytoskeleton . Behaves as an integral membrane protein of the mitochondrion des
• Protein Description: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity)..
• Protein Sequence: MLARAARGTGALLLRGSVQASGRIPRRASSGLPRNTVILFVPQQEAWVVERMGRFHRILEPGLNVLIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNANIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAGALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTVLLPSNPSDVTSMVAQAMGVYGALTKAPVPGAQNSSEARRDVQTTDTSIEELGRVKLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	GALLLRGSVQASGRI CCEEEECCCCCCCCC	12.48	-
29	Phosphorylation	GRIPRRASSGLPRNT CCCCCCCCCCCCCCE	24.11	28432305
30	Phosphorylation	RIPRRASSGLPRNTV CCCCCCCCCCCCCEE	43.28	28432305
114	Acetylation	LRIMDPYKASYGVED EEECCCCHHHCCCCC	35.92	22902405
124	Phosphorylation	YGVEDPEYAVTQLAQ CCCCCHHHHHHHHHH	16.26	-
140	Acetylation	TMRSELGKLSLDKVF HHHHHHHHHCHHHHH	47.75	22902405
145	Acetylation	LGKLSLDKVFRERES HHHHCHHHHHHHHHH	48.87	22902405
145	Succinylation	LGKLSLDKVFRERES HHHHCHHHHHHHHHH	48.87	-
145	Succinylation	LGKLSLDKVFRERES HHHHCHHHHHHHHHH	48.87	-
210	Phosphorylation	TVLESEGTRESAINV EECCCCCCHHHHHHH	27.49	26022182
221	Acetylation	AINVAEGKKQAQILA HHHHHHHHHHHHHHH	32.97	22902405
233	Acetylation	ILASEAEKAEQINQA HHHHHHHHHHHHHHH	65.36	25786129
250	Acetylation	EASAVLAKAKAKAEA HHHHHHHHHHHHHHH	46.38	22902405
330	Phosphorylation	PVPGAQNSSEARRDV CCCCCCCCHHHHHHH	19.92	-
339	Phosphorylation	EARRDVQTTDTSIEE HHHHHHHCCCCCHHH	26.87	30181290
340	Phosphorylation	ARRDVQTTDTSIEEL HHHHHHCCCCCHHHH	21.86	30181290
342	Phosphorylation	RDVQTTDTSIEELGR HHHHCCCCCHHHHCC	29.52	30181290
343	Phosphorylation	DVQTTDTSIEELGRV HHHCCCCCHHHHCCC	30.71	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
17	S	Phosphorylation	Kinase	PRKCZ	P09217	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STML2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STML2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of STML2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.