STLP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STLP2_ARATH
• UniProt AC: Q39221
• Protein Name: SEC12-like protein 2
• Gene Name: STL2P
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 393
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein. Endoplasmic reticulum and the early Golgi..
• Protein Description: Required for the formation or budding of transport vesicles from the ER..
• Protein Sequence: MANQSTETNQPSNMQTYGVPIYAADWIPEVDVRSKIIMDPEKSEDDDESSSSSSSSRSCIVLSGGGGEGRSGISNVILICRVDLNTNSLSEQPLGRLVVGSDLPYRMAVHPREGGLICALPNSCKLFHWEDIMSREDNQAGESEEVIKELRDVGQQLALAFNPEGSVLAAGAEDGTLRVFKWPSMNTLLNESQAHSSVKCLTFSESGQFLVSLGGPVCRVWDVNASAAVASLSKEKDEMFASCRFSVDSAGNEVLYIAANTERGGSIITCDTKLWKRKWSKPIKKNSISAFNVSADGKLLAIGTLEGDVLILESTRMQTIQVVKKAHLGLVTALTFSPDSRGLVSVSFDSRARLTMIEQKGDKPGVRWWLLVLLIVLLYVVAYYYMKAKGIIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANQSTETN ------CCCCCCCCC	23.83	22223895
34	Phosphorylation	IPEVDVRSKIIMDPE CCCCCCCCCEEECCC	28.23	19376835
38	Sulfoxidation	DVRSKIIMDPEKSED CCCCCEEECCCCCCC	8.83	23289948
43	Phosphorylation	IIMDPEKSEDDDESS EEECCCCCCCCCCCC	44.59	30291188
49	Phosphorylation	KSEDDDESSSSSSSS CCCCCCCCCCCCCCC	42.38	15308754
50	Phosphorylation	SEDDDESSSSSSSSR CCCCCCCCCCCCCCC	31.99	15308754
51	Phosphorylation	EDDDESSSSSSSSRS CCCCCCCCCCCCCCE	43.44	27532006
52	Phosphorylation	DDDESSSSSSSSRSC CCCCCCCCCCCCCEE	35.87	27532006
53	Phosphorylation	DDESSSSSSSSRSCI CCCCCCCCCCCCEEE	35.87	19376835
54	Phosphorylation	DESSSSSSSSRSCIV CCCCCCCCCCCEEEE	33.99	19376835
55	Phosphorylation	ESSSSSSSSRSCIVL CCCCCCCCCCEEEEE	31.55	19376835
56	Phosphorylation	SSSSSSSSRSCIVLS CCCCCCCCCEEEEEE	30.11	19376835
246	Phosphorylation	MFASCRFSVDSAGNE HCEECCEEECCCCCE	12.98	23776212
249	Phosphorylation	SCRFSVDSAGNEVLY ECCEEECCCCCEEEE	35.60	23776212
256	Phosphorylation	SAGNEVLYIAANTER CCCCEEEEEEEECCC	8.16	23776212
261	Phosphorylation	VLYIAANTERGGSII EEEEEEECCCCCCEE	23.49	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STLP2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STLP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STLP2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of STLP2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND MASSSPECTROMETRY.
PubMed: 19376835

"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Mol. Cell. Proteomics 2:1234-1243(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.
PubMed: 14506206