dbPTM

STK35_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STK35_MOUSE
UniProt AC	Q80ZW0
Protein Name	Serine/threonine-protein kinase 35
Gene Name	Stk35
Organism	Mus musculus (Mouse).
Sequence Length	539
Subcellular Localization	Nucleus. Nucleus, nucleolus. Cytoplasm. When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers..
Protein Description
Protein Sequence	MGHQESPLTRAAAGGAAYIKRLRKVLSWRELGDGHGNLEAEASPGSVAVITRAAPRRATRSARLPASRPTRLCRQARLGTDHPPARAPRGNRFARKRNSAGQITIQGPAPPHLGARRRDEARGARAAPLLLPPPPAAMETGKENGARRGTKSPERKRRSPVQRVLCEKLRPAAQAMDPAGAEVPGEAFLARRRPDGGGGDVPARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPCYLWFVMEYCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGVKQLLKDMLAANPQDRPDAFELETRMDQVTCAA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGHQESPLTRAAA --CCCCCCHHHHHHH	20.74	30635358
9	Phosphorylation	GHQESPLTRAAAGGA CCCCCHHHHHHHCHH	22.96	30635358
390	Phosphorylation	KVADFGLSKVCAGLA EEHHHCHHHHHHCCC	24.34	29472430
415	Phosphorylation	KNVNVNKYWLSSACG CCCCCCHHHHHHHCC	13.33	25293948
418	Phosphorylation	NVNKYWLSSACGSDF CCCHHHHHHHCCCCE	11.18	25293948
419	Phosphorylation	VNKYWLSSACGSDFY CCHHHHHHHCCCCEE	25.96	25293948
423	Phosphorylation	WLSSACGSDFYMAPE HHHHHCCCCEEECHH	25.16	25293948
426	Phosphorylation	SACGSDFYMAPEVWE HHCCCCEEECHHHHC	9.43	25293948
461	Phosphorylation	ERITFIDSETKKELL HHHHCCCCCHHHHHH	42.20	-
463	Phosphorylation	ITFIDSETKKELLGT HHCCCCCHHHHHHHH	51.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STK35_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STK35_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STK35_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of STK35_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STK35_MOUSE

Related Literatures of Post-Translational Modification