STIP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STIP1_RAT
• UniProt AC: O35814
• Protein Name: Stress-induced-phosphoprotein 1
• Gene Name: Stip1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 543
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. [PubMed: 9528774]
• Protein Sequence: MEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNLQLKEGLQNMEARLAERKFMNPFNLPNLYQKLENDPRTRTLLSDPTYRELIEQLQNKPSDLGTKLQDPRVMTTLSVLLGVDLGSMDEEEEAATPPPPPPPKKEAKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDKALKHYDKAKELDPTNMTYITNQAAVHFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEERYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPRDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEQVNELK -------CHHHHHHH	7.99	-
8	Acetylation	MEQVNELKEKGNKAL CHHHHHHHHHHHHHH	51.72	22902405
16	Phosphorylation	EKGNKALSAGNIDDA HHHHHHHHCCCHHHH	38.70	27097102
68	Acetylation	GCKTVDLKPDWGKGY CCCCCCCCCCCCCCH	36.15	22902405
73	Acetylation	DLKPDWGKGYSRKAA CCCCCCCCCHHHHHH	50.88	22902405
100	Acetylation	RTYEEGLKHEANNLQ HHHHHHHHHHHHHHH	50.70	22902405
162	Ubiquitination	LIEQLQNKPSDLGTK HHHHHHCCCHHHCCC	32.70	-
162	Acetylation	LIEQLQNKPSDLGTK HHHHHHCCCHHHCCC	32.70	22902405
164	Phosphorylation	EQLQNKPSDLGTKLQ HHHHCCCHHHCCCCC	47.26	25575281
189	Phosphorylation	LLGVDLGSMDEEEEA HHCCCCCCCCHHHHH	30.29	27097102
198	Phosphorylation	DEEEEAATPPPPPPP CHHHHHCCCCCCCCC	43.29	27097102
229	Acetylation	KKQALKEKELGNDAY HHHHHHHHHHCCHHH	57.56	22902405
243	Acetylation	YKKKDFDKALKHYDK HHHHHHHHHHHHHHH	56.46	22902405
301	Acetylation	EDYRQIAKAYARIGN HHHHHHHHHHHHHCC	43.49	-
312	Acetylation	RIGNSYFKEERYKDA HHCCCCCCCHHHHHH	50.89	22902405
317	Acetylation	YFKEERYKDAIHFYN CCCCHHHHHHHHHHH	47.07	22902405
325	Acetylation	DAIHFYNKSLAEHRT HHHHHHHHHHHHHCC	35.15	22902405
332	Phosphorylation	KSLAEHRTPDVLKKC HHHHHHCCHHHHHHH	26.25	-
337	Acetylation	HRTPDVLKKCQQAEK HCCHHHHHHHHHHHH	51.88	22902405
344	Acetylation	KKCQQAEKILKEQER HHHHHHHHHHHHHHH	57.25	-
347	Acetylation	QQAEKILKEQERLAY HHHHHHHHHHHHHHH	61.91	22902405
354	Phosphorylation	KEQERLAYINPDLAL HHHHHHHHCCHHHHH	13.06	-
364	Acetylation	PDLALEEKNKGNECF HHHHHHHHCCCCCHH	55.36	22902405
395	Acetylation	KRNPRDAKLYSNRAA HHCCCCHHHHCCHHH	52.85	22902405
442	Acetylation	AAALEAMKDYTKAMD HHHHHHHHHHHHHHH	55.41	22902405
446	Acetylation	EAMKDYTKAMDVYQK HHHHHHHHHHHHHHH	35.17	22902405
476	Phosphorylation	QRCMMAQYNRHDSPE HHHHHHHHCCCCCHH	12.48	23984901
481	Phosphorylation	AQYNRHDSPEDVKRR HHHCCCCCHHHHHHH	24.86	29779826
513	Acetylation	LILEQMQKDPQALSE HHHHHHHHCHHHHHH	67.06	22902405
530	Acetylation	KNPVIAQKIQKLMDV CCHHHHHHHHHHHHC	37.77	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STIP1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STIP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STIP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of STIP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.