dbPTM

STEA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STEA4_HUMAN
UniProt AC	Q687X5
Protein Name	Metalloreductase STEAP4
Gene Name	STEAP4
Organism	Homo sapiens (Human).
Sequence Length	459
Subcellular Localization	Cell membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein . Early endosome membrane Multi-pass membrane protein .
Protein Description	Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. [PubMed: 18430367]
Protein Sequence	MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MEKTCIDALP -----CCCCHHHEEC	47.61	29967540
18	Ubiquitination	LTMNSSEKQETVCIF CCCCCCCCCEEEEEE	56.22	21963094
33	Phosphorylation	GTGDFGRSLGLKMLQ ECCHHHHHHCHHHHC	27.45	-
43	Phosphorylation	LKMLQCGYSVVFGSR HHHHCCCCEEEECCC	13.10	28111955
44	Phosphorylation	KMLQCGYSVVFGSRN HHHCCCCEEEECCCC	9.33	28111955
49	Phosphorylation	GYSVVFGSRNPQKTT CCEEEECCCCCCCCE	19.88	28111955
54	Ubiquitination	FGSRNPQKTTLLPSG ECCCCCCCCEECCCC	44.74	29967540
60	Phosphorylation	QKTTLLPSGAEVLSY CCCEECCCCCCEECH	51.08	27251275
72	2-Hydroxyisobutyrylation	LSYSEAAKKSGIIII ECHHHHHHHCCEEEE	55.29	-
72	Ubiquitination	LSYSEAAKKSGIIII ECHHHHHHHCCEEEE	55.29	29901268
109	Ubiquitination	VDISNNLKINQYPES EECCCCCCCCCCCCC	41.56	29967540
161	Ubiquitination	FVCGNDSKAKQRVMD EEECCCHHHHHHHHH	63.57	21963094
176	Phosphorylation	IVRNLGLTPMDQGSL HHHHCCCCCCCHHCH	18.12	-
182	Phosphorylation	LTPMDQGSLMAAKEI CCCCCHHCHHCHHHH	14.89	-
187	Ubiquitination	QGSLMAAKEIEKYPL HHCHHCHHHHHHCCC	50.08	21963094
187	Acetylation	QGSLMAAKEIEKYPL HHCHHCHHHHHHCCC	50.08	27452117
225	Phosphorylation	CVIRDVIYPYVYEKK HHHHHHHHHHHHCCC	6.59	-
323	N-linked_Glycosylation	YVRWRLGNLTVTQAI HHHHHHCCEEHHHHH	36.81	30337524
332	Ubiquitination	TVTQAILKKENPFST EHHHHHHHCCCCCCC	52.51	21963094
333	Ubiquitination	VTQAILKKENPFSTS HHHHHHHCCCCCCCC	60.31	22817900
408	Phosphorylation	YGGKRFLSPSNLRWY HCCCCCCCHHHHCCH	24.46	-
410	Phosphorylation	GKRFLSPSNLRWYLP CCCCCCHHHHCCHHH	45.16	22985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STEA4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STEA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STEA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of STEA4_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STEA4_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323, AND MASSSPECTROMETRY.	19159218 [Abstract]