STAP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAP1_MOUSE
• UniProt AC: Q9JM90
• Protein Name: Signal-transducing adaptor protein 1
• Gene Name: Stap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 297
• Subcellular Localization: Nucleus. Cytoplasm . Mitochondrion.
• Protein Description: May function as an adapter molecule downstream of KIT in the proliferation or differentiation of hematopoietic stem cells..
• Protein Sequence: MMAKKPPKPAPRRIFQERLKITALPLYFEGFLLVKRSDHQEYKHYWTELRGTTLFFYTDKKSTIYVGKLDIIDLVCLTGQHSTEKNCAKFTLVLPKEEVHVKTENTESGEEWRGFILTVTELTVPQHVSLLPGQVIRLHEVLEREKKRRIETDQLPLMPPEKEKEPVQDYADVLNPLPECFYAVSRKEATAMLEKNPSWGNMILRPGSDSKNYSITIRQEIEMPRIKHFKVTRTGNNYTIELEKPVTLPNLFSVIDYFVKETRGNLRPFIHSADDNFGQDPNIEDRSEKFKKNPHNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	FFYTDKKSTIYVGKL EEEECCCCEEEEECC	26.27	25367039
63	Phosphorylation	FYTDKKSTIYVGKLD EEECCCCEEEEECCE	25.80	25367039
65	Phosphorylation	TDKKSTIYVGKLDII ECCCCEEEEECCEEE	11.84	25367039
170	Phosphorylation	EKEPVQDYADVLNPL CCCCCCCHHHHHCCC	6.39	25159016
208	Phosphorylation	NMILRPGSDSKNYSI CEEECCCCCCCCEEE	41.20	20531401
214	Phosphorylation	GSDSKNYSITIRQEI CCCCCCEEEEEEEEE	23.73	20531401
216	Phosphorylation	DSKNYSITIRQEIEM CCCCEEEEEEEEEEC	12.27	28285833

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSF1R_MOUSE	Csf1r	physical	10679268
LCK_MOUSE	Lck	physical	10679268

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-170, AND MASSSPECTROMETRY.
PubMed: 17947660