STAM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAM1_MOUSE
• UniProt AC: P70297
• Protein Name: Signal transducing adapter molecule 1
• Gene Name: Stam
• Organism: Mus musculus (Mouse).
• Sequence Length: 548
• Subcellular Localization: Cytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity)..
• Protein Sequence: MPLFATNPFDQDVEKATSELNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVATKKEEEDLAKAIELSLKEQRQQSAPVSTLYPSTSNLLTNHQHEGRKVRAVYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGVGLFPSNFVTADLTAEPEMIKTEKKTVQFNDDVQIETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDNQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQSQQYYLQSSAVSASQVYPGPAQSGTYLVAGSAQMTHLQSYSLPPEQLSSISQGAVPSSANQALPSQQTQASYPNAMVSSVQGNSYPSQASIYSPPAAAAAAAAAAVVPVPVPADVTIYQNAGPTMSQVPNYTLTSSTLPQTGGSQQPPQPQQAYSQKALL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
91	Phosphorylation	VCSRDFASEVSNVLN ECCHHHHHHHHHHHH	38.23	22817900
133	Ubiquitination	SLISAMIKNLKEQGV HHHHHHHHHHHHCCC	43.04	-
136	Ubiquitination	SAMIKNLKEQGVTFP HHHHHHHHHCCCCCC	58.34	-
147	Phosphorylation	VTFPAIGSQAAEQAK CCCCCCCHHHHHHHH	15.55	29899451
154	Ubiquitination	SQAAEQAKASPALVA HHHHHHHHCCCCEEE	49.44	-
156	Phosphorylation	AAEQAKASPALVAKD HHHHHHCCCCEEECC	15.25	25521595
162	Ubiquitination	ASPALVAKDPGTVAT CCCCEEECCCCCCCC	57.91	-
171	Ubiquitination	PGTVATKKEEEDLAK CCCCCCCHHHHHHHH	67.03	-
185	Ubiquitination	KAIELSLKEQRQQSA HHHHHHHHHHHHHCC	48.72	-
191	Phosphorylation	LKEQRQQSAPVSTLY HHHHHHHCCCHHHCC	26.63	29472430
195	Phosphorylation	RQQSAPVSTLYPSTS HHHCCCHHHCCCCHH	16.19	29472430
196	Phosphorylation	QQSAPVSTLYPSTSN HHCCCHHHCCCCHHC	30.46	29472430
198	Phosphorylation	SAPVSTLYPSTSNLL CCCHHHCCCCHHCCC	8.67	29472430
200	Phosphorylation	PVSTLYPSTSNLLTN CHHHCCCCHHCCCCC	30.80	29472430
201	Phosphorylation	VSTLYPSTSNLLTNH HHHCCCCHHCCCCCC	19.68	29472430
202	Phosphorylation	STLYPSTSNLLTNHQ HHCCCCHHCCCCCCC	29.80	29472430
206	Phosphorylation	PSTSNLLTNHQHEGR CCHHCCCCCCCCCCC	33.55	29472430
276	Ubiquitination	TAEPEMIKTEKKTVQ CCCHHHEECCCCEEE	49.69	-
353	Ubiquitination	KLEDIDRKHSELSEL HHHHHHHHCHHHHHH	47.97	-
381	Phosphorylation	LMNEDPMYSMYAKLQ HCCCCHHHHHHHHHH	8.82	22817900
384	Phosphorylation	EDPMYSMYAKLQSQQ CCHHHHHHHHHHHCC	8.47	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAM1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STAM1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.