STAG3_MOUSE - dbPTM
STAG3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STAG3_MOUSE
UniProt AC O70576
Protein Name Cohesin subunit SA-3
Gene Name Stag3
Organism Mus musculus (Mouse).
Sequence Length 1240
Subcellular Localization Nucleus . Chromosome . Chromosome, centromere . Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosom
Protein Description Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I..
Protein Sequence MPTLWSPSTQHHGSSSGSESSPLQKSVRRAQMALSPCSSSILPCDDRDSQGTAEWDSPSTNEDSDFEDSLRRNVKKRAAKQPPKAVPAAKHRKKQSRIVSSGNGKNESVPSTNYLFDAVKAARSCMQSLVDEWLDNYKQDENAGFLELINFFIRACGCKSTVTPEMFKTMSNSEIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVYQCQYSLLYDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQRQYEAERNKGPEQRAPERLESLLEKRKEFQENQEDIEGMMNAIFRGVFVHRYRDILPEIRAICIEEIGYWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSLRMELFTNRFKDRMVSMVMDRECEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYISNRAMASSAGEFVYWKIFHPECGAKAVSDRERRRSPQAQKTFIYLLLAFFMESEHHNHAAYLVDSLWDCAGSYLKDWESLTNLLLQKDQNLGDMQERMLIEILVSSARQAAEGHPPVGRITGKKSLTAKERKLQAYDKMKLAEHLIPLLPQLLAKFSADAENVAPLLQLLSYFDLSIYCTQRLEKHLELLLQQLQEVVVKHVEPEVLEAAAHALYLLCKPEFTFFSRVDFARSQLVDFLTDRFQQELDDLMQSSFLDEDEVYSLTATLKRLSAFYNAHDLTRWEISEPCSRLLRKAVDTGEVPHQVILPALTLVYFSILWTVTHISESTSHKQLMSLKKRMVAFCELCQSCLSDVDPEIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFPEATLQSELASFLMDHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVLELDAASDVFKHYNKFYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQGPQGLTELPAFIEMRDLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPPAGSSHEPPNLAFLELLSEFSPRLFHQDKRLLLSYLEKCLQRVSKAPNHPWGPVTTYCHSLHPLEITAEASPRGPPHSKKRCVEGPCRPQEEESSSQEESLQLNSGPTTPTLTSTAVKRKQSLRTVGKKQKGRPGPGPGPGPELICSQQLLGTQRLKMSSAPCFQIRCDPSGSGLGKQLTRLSLMEEDEEEELRLLDEEWQRGDKMLHSPSSPSEHGLDLLDTTELNMEDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPTLWSPSTQ
-----CCCCCCCCCC		53.3621183079
6Phosphorylation--MPTLWSPSTQHHG
--CCCCCCCCCCCCC		16.4625293948
8PhosphorylationMPTLWSPSTQHHGSS
CCCCCCCCCCCCCCC		34.8722817900
9PhosphorylationPTLWSPSTQHHGSSS
CCCCCCCCCCCCCCC		34.9925293948
14PhosphorylationPSTQHHGSSSGSESS
CCCCCCCCCCCCCCC		19.5825293948
15PhosphorylationSTQHHGSSSGSESSP
CCCCCCCCCCCCCCH		43.2225293948
16PhosphorylationTQHHGSSSGSESSPL
CCCCCCCCCCCCCHH		48.3021183079
18PhosphorylationHHGSSSGSESSPLQK
CCCCCCCCCCCHHHH		35.9325293948
20PhosphorylationGSSSGSESSPLQKSV
CCCCCCCCCHHHHHH		38.6625293948
21PhosphorylationSSSGSESSPLQKSVR
CCCCCCCCHHHHHHH		26.1025293948
269PhosphorylationVKVALQLSLHKDNNQ
HHHHHHHHHCCCCCH		18.5722324799
297PhosphorylationRAPERLESLLEKRKE
HHHHHHHHHHHHHHH		42.7322817900
392PhosphorylationLYSNQELSLRMELFT
HCCCCCHHHHHHHHH		17.1225159016
408PhosphorylationRFKDRMVSMVMDREC
HHHHHHHHHHCCCHH		9.0520139300
1043PhosphorylationQDKRLLLSYLEKCLQ
HCHHHHHHHHHHHHH		27.8622942356
1044PhosphorylationDKRLLLSYLEKCLQR
CHHHHHHHHHHHHHH		20.8928833060
1076PhosphorylationSLHPLEITAEASPRG
CCCCEEECEECCCCC		14.7425293948
1080PhosphorylationLEITAEASPRGPPHS
EEECEECCCCCCCCC		13.4625293948
1103PhosphorylationCRPQEEESSSQEESL
CCCCCCCCCCHHHHH		38.2721183079
1104PhosphorylationRPQEEESSSQEESLQ
CCCCCCCCCHHHHHH		39.0421183079
1131PhosphorylationTAVKRKQSLRTVGKK
HHHHHHHHHHCCCCC		23.8924453211
1137AcetylationQSLRTVGKKQKGRPG
HHHHCCCCCCCCCCC		47.937743629
1138AcetylationSLRTVGKKQKGRPGP
HHHCCCCCCCCCCCC		51.847743637
1140AcetylationRTVGKKQKGRPGPGP
HCCCCCCCCCCCCCC		66.817743645
1192PhosphorylationGKQLTRLSLMEEDEE
HHHHHHHHCCCCCHH		23.5225293948
1218PhosphorylationRGDKMLHSPSSPSEH
HCCCCCCCCCCCCCC		23.6322817900
1220PhosphorylationDKMLHSPSSPSEHGL
CCCCCCCCCCCCCCC		58.8719060867
1221PhosphorylationKMLHSPSSPSEHGLD
CCCCCCCCCCCCCCC		35.5122817900
1223PhosphorylationLHSPSSPSEHGLDLL
CCCCCCCCCCCCCCC		44.1425293948
1232PhosphorylationHGLDLLDTTELNMED
CCCCCCCCCCCCCCC		23.3425293948
1233PhosphorylationGLDLLDTTELNMEDF
CCCCCCCCCCCCCCC		37.8425293948
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STAG3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STAG3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STAG3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of STAG3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STAG3_MOUSE

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Related Literatures of Post-Translational Modification

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