STA5A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STA5A_RAT
• UniProt AC: Q62771
• Protein Name: Signal transducer and activator of transcription 5A
• Gene Name: Stat5a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 793
• Subcellular Localization: Cytoplasm. Nucleus. Mostly cytoplasmic during pregnancy, whereas it becomes predominantly nuclear during early lactation. It is translocated into the nucleus in response to phosphorylation (By similarity)..
• Protein Description: Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation..
• Protein Sequence: MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFVLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFGQLAQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELVEKHQKTLQLLRKQQTIILDDELIQWKRGQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNRRSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGANATYMDQAPSPVVCPQAHYNMYPPNPDPVLDQDGEFDLDETMDVARHVEELLRRPMDSLDPRLSPPAGLFTSARSSLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	LKIKLGHYATQLQNT EEEEHHHHHHHHHHH	15.00	-
127	Phosphorylation	VREANNCSSPAGVLV HHHHHCCCCCCHHHH	41.29	27097102
128	Phosphorylation	REANNCSSPAGVLVD HHHHCCCCCCHHHHH	22.44	27097102
347	Acetylation	QVLKTQTKFAATVRL CCCCCCCCCHHHHHH	24.16	-
682	Phosphorylation	KDEVFAKYYTPVLAK CCHHHHHHHHHHHHH	14.78	-
694	Phosphorylation	LAKAVDGYVKPQIKQ HHHHHCCCCCHHHHH	10.80	12376552
725	Phosphorylation	TYMDQAPSPVVCPQA CCCCCCCCCEECCCC	33.08	-
779	Phosphorylation	DSLDPRLSPPAGLFT HHCCCCCCCCCCHHC	30.07	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
694	Y	Phosphorylation	Kinase	JAK2	Q62689	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STA5A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STA5A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of STA5A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Analysis of STAT1 activation by six FGFR3 mutants associated withskeletal dysplasia undermines dominant role of STAT1 in FGFR3signaling in cartilage.";
Krejci P., Salazar L., Kashiwada T.A., Chlebova K., Salasova A.,Thompson L.M., Bryja V., Kozubik A., Wilcox W.R.;
PLoS ONE 3:E3961-E3961(2008).
Cited for: FUNCTION, AND PHOSPHORYLATION AT TYR-694 IN RESPONSE TO CONSTITUTIVELYACTIVATED FGFR3.
PubMed: 19088846