SSR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSR1_HUMAN
• UniProt AC: P30872
• Protein Name: Somatostatin receptor type 1
• Gene Name: SSTR1
• Organism: Homo sapiens (Human).
• Sequence Length: 391
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins..
• Protein Sequence: MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MFPNGTASSPS ----CCCCCCCCCCC	49.54	UniProtKB CARBOHYD
44	N-linked_Glycosylation	GMEEPGRNASQNGTL CCCCCCCCCCCCCCC	50.27	UniProtKB CARBOHYD
48	N-linked_Glycosylation	PGRNASQNGTLSEGQ CCCCCCCCCCCCCCC	42.81	UniProtKB CARBOHYD
81	Phosphorylation	CGNSMVIYVILRYAK HCCHHHHHHHHHHHC	3.09	25884760
86	Phosphorylation	VIYVILRYAKMKTAT HHHHHHHHHCCCCCC	13.71	22817900
118	Phosphorylation	VPFLVTSTLLRHWPF HHHHHHHHHHHCCHH	22.05	-
135	Phosphorylation	LLCRLVLSVDAVNMF HHHHHHHCHHHHHHH	15.52	-
339	S-palmitoylation	RSFQRILCLSWMDNA HHHHHHHHHHHHCCC	2.35	-
364	Phosphorylation	ALKSRAYSVEDFQPE HHHCCCCCHHHCCCH	20.32	26657352
383	Phosphorylation	GGVFRNGTCTSRITT CCCCCCCEECCCEEC	19.03	-
385	Phosphorylation	VFRNGTCTSRITTL- CCCCCEECCCEECC-	22.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM5_HUMAN	PRMT5	physical	10734105

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.