SRP72_CANLF - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRP72_CANLF
• UniProt AC: P33731
• Protein Name: Signal recognition particle subunit SRP72
• Gene Name: SRP72
• Organism: Canis lupus familiaris (Dog) (Canis familiaris).
• Sequence Length: 671
• Subcellular Localization: Cytoplasm. Endoplasmic reticulum.
• Protein Description: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function..
• Protein Sequence: MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNAACALIGQGQLSQAMKILQKAEDLCRRSLSEDSDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSSAHLSLIREAANFKLKYGRKKEAISDLEQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSPGATYIRKKGGKVAGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATASASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Blocked amino end (Ala)	------MASGGSGGV ------CCCCCCCCC		-
2	Acetylation	------MASGGSGGV ------CCCCCCCCC		-
2	Blocked amino end	------MASGGSGGV ------CCCCCCCCC		-
571	Phosphorylation	KNYDPKVTPDPERWL CCCCCCCCCCHHHCC		-
618	Phosphorylation	SELDASKTVSSPPTS CCCCCCCCCCCCCCC		-
630	Phosphorylation	PTSPRPGSAATASAS CCCCCCCCCCCCCCC		-
635	Phosphorylation	PGSAATASASTSNII CCCCCCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRP72_CANLF !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRP72_CANLF !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRP72_CANLF !!

Protein-Protein Interaction

Oops, there are no PPI records of SRP72_CANLF !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.