dbPTM

SRP68_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRP68_SCHPO
UniProt AC	O74436
Protein Name	Signal recognition particle subunit srp68
Gene Name	srp68
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	597
Subcellular Localization	Cytoplasm .
Protein Description	Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. Srp68 binds the 7S RNA (By similarity)..
Protein Sequence	MDPHVKLSTSLVIIAFRYLPNNFNDSRLGCDNLSTVGLCLKNGTGEVLFSGLIKQMANFYIFPLLLEARSDHFYEGNEYIKYLSHRIHGLRKSLHITQRGGKPKSSVDKRYAEILLFNADRAFQQFVFLRSSQRRHALRRLKRADQFGKELVSFTNAFDCNDHIFYLEAIAFAKYIEGTLNYEKRDWEGSLSAFSISRLSFLVLQNKIDTLAEHEKSVLGELQNQIDSNLRYVAQRTGLQNQTKSLDILMLSSIPKDEEVIQHVNSVDSEILQMTGDEQDSLQTITVIEWRDQRVKIEHPDVVLALYAIHDVKNSPGTIDSKRDRLLAAWARAEEITKSVLDNTGLEDEQKFQTLSICYTYLAYNVVLLRIQRDLAVENDSELVASQAQLRSRQSLYDSIIKNIEIAKELPGIARDTGMTAQLEAQISLAKSKRCQAIADAYQAQDKLASLAMCVRAASYLQQVNDILRNFEEKPHLIAFDIIPELKKDEKELKKKILLLQSLASMGNINQPPKNLSLVETLDSYQTLAELEPSWNLTDADIRAIPAKPLFFDLAITYLGQQTSFDKKKAQPEKPVTSVSKEPKQKNKGFFSSLLGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
593	Phosphorylation	KNKGFFSSLLGR--- CCCCCHHHHHCC---	23.58	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRP68_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRP68_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRP68_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SRP68_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRP68_SCHPO

Related Literatures of Post-Translational Modification