SRP14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRP14_MOUSE
• UniProt AC: P16254
• Protein Name: Signal recognition particle 14 kDa protein
• Gene Name: Srp14
• Organism: Mus musculus (Mouse).
• Sequence Length: 110
• Subcellular Localization: Cytoplasm.
• Protein Description: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding..
• Protein Sequence: MVLLESEQFLTELTRLFQKCRSSGSVFITLKKYDGRTKPIPRKSSVEGLEPAENKCLLRATDGKRKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKSKKSKPAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVLLESEQFLTEL --CCCCCHHHHHHHH	36.35	25168779
11	Phosphorylation	LESEQFLTELTRLFQ CCHHHHHHHHHHHHH	30.18	25168779
14	Phosphorylation	EQFLTELTRLFQKCR HHHHHHHHHHHHHHH	21.06	25168779
22	Phosphorylation	RLFQKCRSSGSVFIT HHHHHHHCCCCEEEE	48.82	24719451
23	Phosphorylation	LFQKCRSSGSVFITL HHHHHHCCCCEEEEE	18.74	24719451
25	Phosphorylation	QKCRSSGSVFITLKK HHHHCCCCEEEEEEE	18.79	24719451
33	Phosphorylation	VFITLKKYDGRTKPI EEEEEEEECCCCCCC	23.26	24719451
37	Phosphorylation	LKKYDGRTKPIPRKS EEEECCCCCCCCCCC	46.86	24719451
43	Ubiquitination	RTKPIPRKSSVEGLE CCCCCCCCCCCCCCC	41.55	-
44	Phosphorylation	TKPIPRKSSVEGLEP CCCCCCCCCCCCCCC	40.68	25521595
45	Phosphorylation	KPIPRKSSVEGLEPA CCCCCCCCCCCCCCC	27.50	27087446
73	Phosphorylation	KISTVVSSKEVNKFQ EEEEEECHHHHCHHH	22.64	28059163
74	Ubiquitination	ISTVVSSKEVNKFQM EEEEECHHHHCHHHH	59.17	-
74	Malonylation	ISTVVSSKEVNKFQM EEEEECHHHHCHHHH	59.17	26320211
78	Ubiquitination	VSSKEVNKFQMAYSN ECHHHHCHHHHHHHH	41.99	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRP14_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRP14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRP14_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SRP14_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.
PubMed: 19367708