SRGEF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRGEF_HUMAN
• UniProt AC: Q9UGK8
• Protein Name: Secretion-regulating guanine nucleotide exchange factor
• Gene Name: SERGEF
• Organism: Homo sapiens (Human).
• Sequence Length: 458
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process..
• Protein Sequence: MEREPSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDPKVTYLSPDAIEDTESQKAMDKERNWKERQSETSTQSQSDWSRNGGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Ubiquitination	QQLNDFCKPRSVRRI HHHCCCCCCCCCEEC	43.38	-
86	Phosphorylation	GQLGLGHTEDIPYFT CCCCCCCCCCCCCCC	33.29	30206219
91	Phosphorylation	GHTEDIPYFTPCKSL CCCCCCCCCCCCHHH	22.03	30206219
93	Phosphorylation	TEDIPYFTPCKSLFG CCCCCCCCCCHHHHC	23.18	30206219
201	Ubiquitination	LPLFFTAKEPSRVTG EEEEEECCCCCCCCC	68.08	-
256	Ubiquitination	AFLPVPQKIEAHCFQ HCCCCCCCEEEEECC	36.12	-
304	Phosphorylation	LGRKLETYEGWKLEK HCCEEEEECCCCCCC	11.76	-
308	Ubiquitination	LETYEGWKLEKQDSF EEEECCCCCCCCCCC	58.59	-
415	Phosphorylation	LVQDPKVTYLSPDAI HCCCCCEEEECHHHC	25.52	27251275
416	Phosphorylation	VQDPKVTYLSPDAIE CCCCCEEEECHHHCC	14.26	28796482
418	Phosphorylation	DPKVTYLSPDAIEDT CCCEEEECHHHCCCC	15.43	21815630
425	Phosphorylation	SPDAIEDTESQKAMD CHHHCCCCHHHHHHH	25.42	24719451
427	Phosphorylation	DAIEDTESQKAMDKE HHCCCCHHHHHHHHH	38.79	17525332
442	Phosphorylation	RNWKERQSETSTQSQ HCHHHHHHHHCCCCH	49.41	22210691
444	Phosphorylation	WKERQSETSTQSQSD HHHHHHHHCCCCHHH	42.17	22210691
445	Phosphorylation	KERQSETSTQSQSDW HHHHHHHCCCCHHHH	22.01	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRGEF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRGEF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRGEF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXOC2_HUMAN	EXOC2	physical	12459492
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, AND MASSSPECTROMETRY.
PubMed: 17525332