SRFB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRFB1_MOUSE
• UniProt AC: Q9CZ91
• Protein Name: Serum response factor-binding protein 1
• Gene Name: Srfbp1 {ECO:0000312|MGI:MGI:1914472}
• Organism: Mus musculus (Mouse).
• Sequence Length: 441
• Subcellular Localization: Cytoplasm, perinuclear region .
• Protein Description: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells..
• Protein Sequence: MAADPLPPSAMVQPGTLNLNNEVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGTEDALLKNQRRAQRLLEEIHAMKELKPDVVTKSALSDDINFEKTCKKPDSTATDRAVARLAGHPLLKKKIDVLKDAVQAFKDARQSAPAAESSESTSGEGRCKDIARSKDDARESQHPERTVVREQKAKDTNTAAKNAASGSKEKLAKTEQAPRAGTTPGSQGRPSGKGAGVNSEHQGAPAPGDSNQGKASTKTPEDSVCEPANNGVSEEEESEGEKEYFDDSTEERFYKQSSASEDSDSGDDFFIGKVRRTRKKESGVHSSAKELKPLPKVPSKTSTLETPWDVRNDKHRPIPEARKFESVFFHSLAGPKSSRRDPREQAPKNKAPDFPENEPPVKKQFTKSAYRGFESVKQTMQAPLHPSWEASRRRKEQQSKIAVFQGKKITFDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	Phosphorylation	DDINFEKTCKKPDST CCCCCHHHCCCCCCC	23.51	30482847
145	Phosphorylation	QSAPAAESSESTSGE HHCCCCCCCCCCCCC	34.38	22871156
146	Phosphorylation	SAPAAESSESTSGEG HCCCCCCCCCCCCCC	27.37	22871156
148	Phosphorylation	PAAESSESTSGEGRC CCCCCCCCCCCCCHH	29.80	29895711
149	Phosphorylation	AAESSESTSGEGRCK CCCCCCCCCCCCHHH	36.38	22871156
214	Phosphorylation	RAGTTPGSQGRPSGK CCCCCCCCCCCCCCC	30.57	-
261	Phosphorylation	EPANNGVSEEEESEG CCCCCCCCHHHHCCC	40.46	25521595
266	Phosphorylation	GVSEEEESEGEKEYF CCCHHHHCCCCHHHC	54.93	25521595
276	Phosphorylation	EKEYFDDSTEERFYK CHHHCCHHHHHHHHH	39.29	25521595
277	Phosphorylation	KEYFDDSTEERFYKQ HHHCCHHHHHHHHHH	49.19	27600695
285	Phosphorylation	EERFYKQSSASEDSD HHHHHHHCCCCCCCC	24.58	25195567
286	Phosphorylation	ERFYKQSSASEDSDS HHHHHHCCCCCCCCC	33.06	25195567
288	Phosphorylation	FYKQSSASEDSDSGD HHHHCCCCCCCCCCC	43.83	20531401
291	Phosphorylation	QSSASEDSDSGDDFF HCCCCCCCCCCCCCE	29.62	25195567
293	Phosphorylation	SASEDSDSGDDFFIG CCCCCCCCCCCCEEH	48.34	19854140
435	Acetylation	KIAVFQGKKITFDD- CEEEECCCCCCCCC-	30.16	22826441
438	Phosphorylation	VFQGKKITFDD---- EECCCCCCCCC----	29.86	22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRFB1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRFB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRFB1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SRFB1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.