SRC8_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRC8_CHICK
• UniProt AC: Q01406
• Protein Name: Src substrate protein p85
• Gene Name: CTTN1
• Organism: Gallus gallus (Chicken).
• Sequence Length: 563
• Subcellular Localization: Cell membrane . Endoplasmic reticulum . Cytoplasm, cytoskeleton . Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendritic spine. Cell projection, dendrite. Cell projection . Cell junction . Membrane, clathrin-coated pit . Cell
• Protein Description: Contributes to the organization of the actin cytoskeleton and cell shape (By similarity). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones, and may play a role in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (By similarity). Plays a role in endocytosis via clathrin-coated pits (By similarity)..
• Protein Sequence: MTVLLLVVLQMWKATAGHSIAVSQDDGADDWETDPDFVNDVSEKEQRWGAKTVKGSGHQEHINIHQLRENVFQEHQTIKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVKGFGGKFGVQTDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGVDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKVQLHESQKDYKSGFGGKFGVQTERQDPSAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMDKNAATFEDIEKPTSTYQKTKPVERVANKTSSIRANLENLAKEKEQEDRRKAEAERAQRMAREKQEQEEARRKLEEQAKAKKQTPPPSPTTQPAEPKTPSSPVYQDAVSYDAESAYKNSSTTYSAEHEPESGYKTTGSDYQEAVSQREAEYEPETVYEVAGAGDHYQAEENTYDEYENELGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
410	Phosphorylation	QAKAKKQTPPPSPTT HHHHHHCCCCCCCCC	46.79	23106611
414	Phosphorylation	KKQTPPPSPTTQPAE HHCCCCCCCCCCCCC	40.42	23106611
426	Phosphorylation	PAEPKTPSSPVYQDA CCCCCCCCCCCCCCC	53.13	23106611
427	Phosphorylation	AEPKTPSSPVYQDAV CCCCCCCCCCCCCCC	21.42	23106611
430	Phosphorylation	KTPSSPVYQDAVSYD CCCCCCCCCCCCCCC	12.22	8578591
462	Phosphorylation	PESGYKTTGSDYQEA CCCCCCCCCHHHHHH	30.45	23106611
477	Phosphorylation	VSQREAEYEPETVYE HHHHHCCCCCCCEEE	43.78	8578591
483	Phosphorylation	EYEPETVYEVAGAGD CCCCCCEEECCCCCC	16.47	8578591
499	Phosphorylation	YQAEENTYDEYENEL CCCCCCCHHHHHHHC	20.54	8578591

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
430	Y	Phosphorylation	Kinase	SRC	P00523	GPS
430	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
477	Y	Phosphorylation	Kinase	SRC	P00523	GPS
477	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
483	Y	Phosphorylation	Kinase	SRC	P00523	GPS
483	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
499	Y	Phosphorylation	Kinase	SRC	P00523	GPS
499	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRC8_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRC8_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCMA1_CHICK	KCNMA1	physical	22174833

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.