SPTN2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPTN2_RAT
• UniProt AC: Q9QWN8
• Protein Name: Spectrin beta chain, non-erythrocytic 2
• Gene Name: Sptbn2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2388
• Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
• Protein Description: Probably plays an important role in neuronal membrane skeleton..
• Protein Sequence: MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAEHLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAEHYHDIKRIAARQNNVARLWDFLREMVAARRERLLLNLELQKVFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQASTRAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEEEIRAHRPTLDALREQAAALPPALSHTPEVQGRVPTLEQHYEELQARAGERARALEAALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQDLGNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRTLGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYFLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQSAGEVERTSRAVEEKFRALCQPMKDRCRRLQASREQHQFHRDVEDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLKERQRTLGTAAAGPELAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGLRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSACIDMGQELLARNHYAAEEISEKLSQLQSRRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEERENEQKRKREEEERRKQPPTSEPMASQPEGSLVDGQRVLDTAWDGTQSKLPPSTQAPSINGVCTDTESSQPLLEQQRLEQSNVPEGPGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSSESAHVATLPARGAELSAQEQMEGTLCRKQEMEAFNKKAANRSWQNVYCVLRRGSLGFYKDARAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSASRGLTRAMTMPPVSQPEGSIVLRSKDGREREREKRFSFFKKNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSTLSPTD ------CCCCCCCCC	43.25	22673903
2	Acetylation	------MSSTLSPTD ------CCCCCCCCC	43.25	-
3	Phosphorylation	-----MSSTLSPTDF -----CCCCCCCCCH	45.27	22673903
4	Phosphorylation	----MSSTLSPTDFD ----CCCCCCCCCHH	40.31	22673903
6	Phosphorylation	--MSSTLSPTDFDSL --CCCCCCCCCHHCC	26.33	22673903
8	Phosphorylation	MSSTLSPTDFDSLEI CCCCCCCCCHHCCEE	46.02	22673903
12	Phosphorylation	LSPTDFDSLEIQGQY CCCCCHHCCEEECCC	28.09	22673903
19	Phosphorylation	SLEIQGQYSDINNRW CCEEECCCCCCCCCC	18.35	22673903
20	Phosphorylation	LEIQGQYSDINNRWD CEEECCCCCCCCCCC	24.91	22673903
31	Phosphorylation	NRWDLPDSDWDNDSS CCCCCCCCCCCCCCH	38.37	22108457
37	Phosphorylation	DSDWDNDSSSARLFE CCCCCCCCHHHHHHH	32.23	22673903
38	Phosphorylation	SDWDNDSSSARLFER CCCCCCCHHHHHHHH	30.77	22673903
39	Phosphorylation	DWDNDSSSARLFERS CCCCCCHHHHHHHHH	22.74	22673903
65	Acetylation	VQKKTFTKWVNSHLA HHHHHHHHHHHHHHH	44.98	22902405
102	Phosphorylation	LEVLSGETLPKPTKG HHHHCCCCCCCCCCC	52.46	25403869
229	Acetylation	LLDFESLKKCNAHYN CCCHHHHHHCCCCCC	65.64	22902405
358	Acetylation	RTVEKPPKFTEKGNL CCCCCCCCCCCCCCE	73.73	22902405
371	Phosphorylation	NLEVLLFTIQSKLRA CEEEEEEEHHHHHHH	20.34	30181290
374	Phosphorylation	VLLFTIQSKLRANNQ EEEEEHHHHHHHCCC	29.79	30181290
393	Phosphorylation	PREGRLISDINKAWE CCCCCCHHHHHHHHH	36.71	25532521
404	Acetylation	KAWERLEKAEHEREL HHHHHHHHHHHHHHH	64.76	22902405
442	Phosphorylation	AMRETWLSENQRLVS HHHHHHHCHHHHHHC	26.51	27097102
449	Phosphorylation	SENQRLVSQDNFGLE CHHHHHHCCCCHHHH	36.09	-
500	Acetylation	AEHYHDIKRIAARQN HHHHHHHHHHHHHCC	43.75	181473
771	Phosphorylation	VDALRLVSSPEVGHD HHHHHHHCCCCCCCC	44.78	22108457
772	Phosphorylation	DALRLVSSPEVGHDE HHHHHHCCCCCCCCH	20.01	22108457
781	Phosphorylation	EVGHDEFSTQALARQ CCCCCHHHHHHHHHH	19.98	25575281
782	Phosphorylation	VGHDEFSTQALARQH CCCCHHHHHHHHHHH	24.15	28689409
912	Phosphorylation	AARVTAVSDIAEQLL HHHHHHHHHHHHHHH	22.34	28689409
922	Phosphorylation	AEQLLKASPPGKDRI HHHHHHCCCCCCCCC	30.00	28689409
959	Phosphorylation	AALTSALSIQNYHLE HHHHHHHHHHCHHEE	23.11	-
983	Phosphorylation	EKTKVIESTQDLGND HHHHHHHHCHHHCHH	21.90	-
1073	Phosphorylation	RLQDFLRSLDDFQAW HHHHHHHCHHHHHHH	37.99	22108457
1213	Acetylation	AADAAIKKLEDFMST HHHHHHHHHHHHHHH	51.50	22902405
1255	Phosphorylation	KIQEKADSIEKRHRK HHHHHHHHHHHHHHH	37.19	29779826
1357	Acetylation	LKVLVSEKLEDLHRR HHHHHHHHHHHHHHH	50.06	22902405
1437	Acetylation	REMAVREKEVEAIQA HHHHHHHHHHHHHHH	57.40	22902405
1469	Acetylation	TSRAVEEKFRALCQP HHHHHHHHHHHHHHH	27.01	22902405
1478	Acetylation	RALCQPMKDRCRRLQ HHHHHHHHHHHHHHH	49.02	22902405
1571	Acetylation	AELQEMWKRLSHELE HHHHHHHHHHHHHHH	42.00	22902405
1574	Phosphorylation	QEMWKRLSHELELRG HHHHHHHHHHHHHCH	20.96	29779826
1622	Phosphorylation	EKAKDELSAQAEVKK HHHHHHHHHHHHHHH	19.11	24972320
1628	Acetylation	LSAQAEVKKHQVLEQ HHHHHHHHHHHHHHH	35.72	8264559
1650	Phosphorylation	TIKQLAASSQDMIDH HHHHHHHHCCCCCCC	23.95	30181290
1651	Phosphorylation	IKQLAASSQDMIDHE HHHHHHHCCCCCCCC	26.02	30181290
1674	Acetylation	IRQAQVDKLYAGLKE EHHHHHHHHHHHHHH	44.53	22902405
1753	Phosphorylation	IGQERVDSANALANG CCHHHHHHHHHHHHC	22.14	22108457
1801	Phosphorylation	GQVLAAAYELQRFLH HHHHHHHHHHHHHHH	16.67	-
1874	Acetylation	QKAYAGDKAEEIGRH HHHHCCCHHHHHHHH	57.70	22902405
1909	Acetylation	LLLDTTDKFRFFKAV HHHCCCCHHHHHHHH	36.03	22902405
1940	Phosphorylation	QERPRDVSSADLVIK CCCCCCCCHHHEEEE	24.89	22108457
1964	Phosphorylation	EARADRFSACIDMGQ HHHHHHHHHHHHHHH	24.11	22108457
1987	Acetylation	AAEEISEKLSQLQSR HHHHHHHHHHHHHHH	46.80	22902405
2038	Phosphorylation	SQEPLVRSAELGCTV CCCCCCCHHCCCCCH	20.72	22108457
2070	Phosphorylation	VAWEERFSALEKLTA HHHHHHHHHHHHHHH	37.86	22673903
2161	Phosphorylation	EQQRLEQSNVPEGPG HHHHHHHCCCCCCCC	30.35	25575281
2169	Phosphorylation	NVPEGPGSGTGDESS CCCCCCCCCCCCCCC	35.99	22108457
2171	Phosphorylation	PEGPGSGTGDESSGP CCCCCCCCCCCCCCC	43.06	25403869
2175	Phosphorylation	GSGTGDESSGPRGER CCCCCCCCCCCCCCC	45.39	30181290
2176	Phosphorylation	SGTGDESSGPRGERQ CCCCCCCCCCCCCCC	51.25	30181290
2184	Phosphorylation	GPRGERQTLPRGPAP CCCCCCCCCCCCCCC	44.97	29779826
2192	Phosphorylation	LPRGPAPSPMPQSRS CCCCCCCCCCCCCCC	35.62	28689409
2197	Phosphorylation	APSPMPQSRSSESAH CCCCCCCCCCCCCCC	28.41	28689409
2199	Phosphorylation	SPMPQSRSSESAHVA CCCCCCCCCCCCCEE	43.64	22108457
2200	Phosphorylation	PMPQSRSSESAHVAT CCCCCCCCCCCCEEC	34.17	22108457
2202	Phosphorylation	PQSRSSESAHVATLP CCCCCCCCCCEECCC	26.14	23984901
2207	Phosphorylation	SESAHVATLPARGAE CCCCCEECCCCCCCC	31.99	25575281
2254	Phosphorylation	YCVLRRGSLGFYKDA EEEEECCCCCHHHCH	24.41	29779826
2258	Phosphorylation	RRGSLGFYKDARAAS ECCCCCHHHCHHHHH	13.22	25575281
2259	Acetylation	RGSLGFYKDARAASA CCCCCHHHCHHHHHC	42.52	22902405
2344	Phosphorylation	PEEPVVPSASRGLTR CCCCCCCCCCCCCCC	27.54	25575281
2346	Phosphorylation	EPVVPSASRGLTRAM CCCCCCCCCCCCCHH	31.08	25575281
2354	Phosphorylation	RGLTRAMTMPPVSQP CCCCCHHCCCCCCCC	26.07	29779826
2359	Phosphorylation	AMTMPPVSQPEGSIV HHCCCCCCCCCCCEE	45.88	25575281
2364	Phosphorylation	PVSQPEGSIVLRSKD CCCCCCCCEEEECCC	14.09	16641100
2382	Phosphorylation	REREKRFSFFKKNK- HHHHHHHCCHHCCC-	33.53	29779826
2385	Acetylation	EKRFSFFKKNK---- HHHHCCHHCCC----	54.12	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPTN2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPTN2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPTN2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SPTN2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2199; THR-2354 ANDSER-2364, AND MASS SPECTROMETRY.
PubMed: 16641100