dbPTM

SPT51_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPT51_ARATH
UniProt AC	Q9STN3
Protein Name	Putative transcription elongation factor SPT5 homolog 1
Gene Name	At4g08350
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1041
Subcellular Localization	Nucleus.
Protein Description	May regulate transcription elongation by RNA polymerase II. May enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity)..
Protein Sequence	MPRSRDEDDELDGDYEALDLEEEEEEDEEEEEERGRGGGGSRRKRGRSNFIDDYAEEDSQEEDDDDEDYGSSRGGKGAASKRKKPSASIFLDREAHQVDDEDEEEEDEAEDDFIVDNGTDLPDERGDRRYERRFLPRDENDEDVEDLERRIQERFSSRHHEEYDEEATEVEQQALLPSVRDPKLWMVKCAIGREREVAVCLMQKFIDRGADLQIRSVVALDHLKNFIYVEADKEAHVKEAIKGMRNIYANQKILLVPIREMTDVLSVESKAIDLSRDTWVRMKIGTYKGDLAKVVDVDNVRQRVTVKLIPRIDLQALASKLDGREVSKKKAFVPPPRFMNIDEARELHIRVERRRDHMTGDYFENIGGMLFKDGFHYKQVSLKSITVQNVTPTFDELEKFNKPSENGEGDFGGLSTLFANRKKGHFMKGDAVIVIKGDLKNLKGWVEKVDEENVLIRSEVKGLPDPLAVNERELCKYFEPGNHVKVVSGTHEGATGMVVKVDQHVLIILSDTTKEHVRVFADHVVESSEVTTGVTKIGDYELHDLVLLDNLSFGVIIRLENEAFQVLKGVPDRPEVALVKLREIKCKLEKKINVQDRYKNVIAVKDDVRVIEGPSKGKQGPVKHIYKGVLFIYDRHHLEHAGFICAKCTSCIVVGGSRSGANRNGGDSLSRYGNFKAPAPVPSSPGRFQRGRGGGYNNSGGRHGGGRGRGDDSLLGTTVKIRLGPFKGYRGPVVEVKGNSVRVELEMKIVTVDRGAISDNVATTPFRDTSRYSMGSETPMHPSRTPLHPYMTPMRDSGATPIHDGMRTPMRDRAWNPYTPMSPPRDNWEDGNPGSWGTSPQYQPGSPPSRAYEAPTPGSGWASTPGGSYSDAGTPRDHGSAYANAPSPYLPSTPGQPMTPSSASYLPGTPGGQPMTPGTGLDVMSPVIGGDAEAWFMPDILVDIHKAGEDTDVGVIRDVSDGTCKVSLGSSGEGDTIMALPSELEIIPPRKSDRVKIVGGQYRGSTGKLIGIDGSDGIVKIDDNLDVKILDLALLAKFVQP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPRSRDEDDEL ----CCCCCCCCCCC	55.61	27531888
54	Phosphorylation	RSNFIDDYAEEDSQE CCCCCCCCCCCCCCC	16.50	19880383
59	Phosphorylation	DDYAEEDSQEEDDDD CCCCCCCCCCCCCCC	42.65	23776212
69	Phosphorylation	EDDDDEDYGSSRGGK CCCCCCCCCCCCCCC	19.50	23776212
72	Phosphorylation	DDEDYGSSRGGKGAA CCCCCCCCCCCCCCC	30.49	23776212
384	Phosphorylation	YKQVSLKSITVQNVT EEEEECEEEEEEECC	28.87	28011693
386	Phosphorylation	QVSLKSITVQNVTPT EEECEEEEEEECCCC	24.11	28011693
615	Phosphorylation	VRVIEGPSKGKQGPV EEEEECCCCCCCCCC	65.97	19880383
683	Phosphorylation	KAPAPVPSSPGRFQR CCCCCCCCCCCCCCC	49.77	23776212
684	Phosphorylation	APAPVPSSPGRFQRG CCCCCCCCCCCCCCC	25.88	23776212
763	Phosphorylation	AISDNVATTPFRDTS CCCCCCCCCCCCCCC	30.62	29654922
764	Phosphorylation	ISDNVATTPFRDTSR CCCCCCCCCCCCCCC	15.64	30291188
778	Phosphorylation	RYSMGSETPMHPSRT CCCCCCCCCCCCCCC	27.84	19880383
785	Phosphorylation	TPMHPSRTPLHPYMT CCCCCCCCCCCCCCC	34.24	30407730
790	Phosphorylation	SRTPLHPYMTPMRDS CCCCCCCCCCCCCCC	11.68	25561503
792	Phosphorylation	TPLHPYMTPMRDSGA CCCCCCCCCCCCCCC	14.21	30407730
797	Phosphorylation	YMTPMRDSGATPIHD CCCCCCCCCCCCCCC	21.69	25561503
800	Phosphorylation	PMRDSGATPIHDGMR CCCCCCCCCCCCCCC	26.71	30407730
808	Phosphorylation	PIHDGMRTPMRDRAW CCCCCCCCCCCCCCC	16.73	25561503
822	Phosphorylation	WNPYTPMSPPRDNWE CCCCCCCCCCCCCCC	32.72	23328941
838	Phosphorylation	GNPGSWGTSPQYQPG CCCCCCCCCCCCCCC	30.86	19880383
839	Phosphorylation	NPGSWGTSPQYQPGS CCCCCCCCCCCCCCC	13.18	30407730
846	Phosphorylation	SPQYQPGSPPSRAYE CCCCCCCCCCCCCCC	40.08	27531888
849	Phosphorylation	YQPGSPPSRAYEAPT CCCCCCCCCCCCCCC	32.69	30407730
856	Phosphorylation	SRAYEAPTPGSGWAS CCCCCCCCCCCCCCC	47.53	30407730
859	Phosphorylation	YEAPTPGSGWASTPG CCCCCCCCCCCCCCC	32.15	30407730
863	Phosphorylation	TPGSGWASTPGGSYS CCCCCCCCCCCCCCC	28.73	30407730
864	Phosphorylation	PGSGWASTPGGSYSD CCCCCCCCCCCCCCC	20.43	30407730
868	Phosphorylation	WASTPGGSYSDAGTP CCCCCCCCCCCCCCC	27.64	30407730
869	Phosphorylation	ASTPGGSYSDAGTPR CCCCCCCCCCCCCCC	17.53	30407730
870	Phosphorylation	STPGGSYSDAGTPRD CCCCCCCCCCCCCCC	23.76	19880383
874	Phosphorylation	GSYSDAGTPRDHGSA CCCCCCCCCCCCCCC	19.51	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPT51_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPT51_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPT51_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SPT51_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPT51_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683, AND MASSSPECTROMETRY.	19376835 [Abstract]