SPT4H_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPT4H_DROME
• UniProt AC: Q9TVQ5
• Protein Name: Transcription elongation factor SPT4
• Gene Name: spt4
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 116
• Subcellular Localization: Nucleus.
• Protein Description: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By similarity)..
• Protein Sequence: MAFDAIPKDLRGLRACLVCSLVKSFDQFETDGCENCEEFLRMKNNKDNVYDHTSNNFDGIIALTTPTDSWVAKWQRLSRFTRGIYAISVSGTLPQSTLRDMKNRGIVYKSRDRSQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MAFDAIPKDLRGLRA CCCCCCCCCHHHHHH	64.38	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPT4H_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPT4H_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPT4H_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCBP2_DROME	Cbp20	physical	25242320
SPT5H_DROME	Spt5	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.