dbPTM

SPT17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPT17_HUMAN
UniProt AC	Q96L03
Protein Name	Spermatogenesis-associated protein 17
Gene Name	SPATA17
Organism	Homo sapiens (Human).
Sequence Length	361
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MATLARLQARSSTVGNQYYFRNSVVDPFRKKENDAAVKIQSWFRGCQVRAYIRHLNRIVTIIQKWWRSFLGRKQYQLTVQVAYYTMMMNLYNAMAVRIQRRWRGYRVRKYLFNYYYLKEYLKVVSETNDAIRKALEEFAEMKEREEKKANLEREEKKRDYQARKMHYLLSTKQIPGIYNSPFRKEPDPWELQLQKAKPLTHRRPKVKQKDSTSLTDWLACTSARSFPRSEILPPINRKQCQGPFRDITEVLEQRYRPLEPTLRVAEPIDELKLAREELRREEWLQNVNDNMFLPFSSYHKNEKYIPSMHLSSKYGPISYKEQFRSENPKKWICDKDFQTVLPSFELFSKYGKLYSKAGQIV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	ARLQARSSTVGNQYY HHHHHHHCCCCCHHH	22.89	22210691
13	Phosphorylation	RLQARSSTVGNQYYF HHHHHHCCCCCHHHC	33.41	22210691
75	Phosphorylation	SFLGRKQYQLTVQVA HHCCCCCHHHHHHHH	14.44	24043423
78	Phosphorylation	GRKQYQLTVQVAYYT CCCCHHHHHHHHHHH	8.05	25262027
83	Phosphorylation	QLTVQVAYYTMMMNL HHHHHHHHHHHHHHH	10.70	24043423
84	Phosphorylation	LTVQVAYYTMMMNLY HHHHHHHHHHHHHHH	4.38	24043423
85	Phosphorylation	TVQVAYYTMMMNLYN HHHHHHHHHHHHHHH	5.96	25262027
91	Phosphorylation	YTMMMNLYNAMAVRI HHHHHHHHHHHHHHH	8.89	25262027
105	Phosphorylation	IQRRWRGYRVRKYLF HHHHHCCHHHHHHHH	9.43	-
115	Phosphorylation	RKYLFNYYYLKEYLK HHHHHHHHHHHHHHH	11.92	-
116	Phosphorylation	KYLFNYYYLKEYLKV HHHHHHHHHHHHHHH	10.84	-
148	Ubiquitination	MKEREEKKANLEREE HHHHHHHHHHHHHHH	45.87	-
167	Phosphorylation	YQARKMHYLLSTKQI HHHHHHHHHHHHCCC	13.07	29759185
170	Phosphorylation	RKMHYLLSTKQIPGI HHHHHHHHHCCCCCC	30.85	24719451
171	Phosphorylation	KMHYLLSTKQIPGIY HHHHHHHHCCCCCCC	27.26	29759185
178	Phosphorylation	TKQIPGIYNSPFRKE HCCCCCCCCCCCCCC	18.59	29759185
180	Phosphorylation	QIPGIYNSPFRKEPD CCCCCCCCCCCCCCC	14.40	29759185
211	Phosphorylation	PKVKQKDSTSLTDWL CCCCCCCCCCHHHHH	27.25	25693802
212	Phosphorylation	KVKQKDSTSLTDWLA CCCCCCCCCHHHHHH	37.58	25693802
213	Phosphorylation	VKQKDSTSLTDWLAC CCCCCCCCHHHHHHH	32.97	25693802
215	Phosphorylation	QKDSTSLTDWLACTS CCCCCCHHHHHHHHC	25.54	25693802
348	Phosphorylation	LPSFELFSKYGKLYS HHHHHHHHHHCHHHH	37.28	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPT17_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPT17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPT17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
KDM1B_HUMAN	KDM1B	physical	26186194
KDM1B_HUMAN	KDM1B	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPT17_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, AND MASSSPECTROMETRY.	17081983 [Abstract]