SPSA1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPSA1_ARATH
• UniProt AC: Q94BT0
• Protein Name: Sucrose-phosphate synthase 1
• Gene Name: SPS1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1043
• Protein Description: Plays a major role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP-glucose and fructose- 6-phosphate. Involved in the regulation of carbon partitioning in the leaves of plants. May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf. Plays a role for sucrose availability that is essential for plant growth and fiber elongation. Required for nectar secretion..
• Protein Sequence: MAGNDWVNSYLEAILDVGQGLDDARSSPSLLLRERGRFTPSRYFVEEVITGYDETDLHRSWVKAVATRSPQERNTRLENMCWRIWNLARQKKQHEEKEAQRLAKRRLEREKGRREATADMSEEFSEGEKGDIISDISTHGESTKPRLPRINSAESMELWASQQKGNKLYLVLISLHGLIRGENMELGRDSDTGGQVKYVVELARALGSMPGVYRVDLLTRQVSSPDVDYSYGEPTEMLTPRDSEDFSDEMGESSGAYIVRIPFGPKDKYIPKELLWPHIPEFVDGAMSHIMQMSNVLGEQVGVGKPIWPSAIHGHYADAGDATALLSGALNVPMLLTGHSLGRDKLEQLLRQGRLSKEEINSTYKIMRRIEGEELSLDVSEMVITSTRQEIDEQWRLYDGFDPILERKLRARIKRNVSCYGRFMPRMVKIPPGMEFNHIVPHGGDMEDTDGNEEHPTSPDPPIWAEIMRFFSNSRKPMILALARPDPKKNITTLVKAFGECRPLRELANLALIMGNRDGIDEMSSTSSSVLLSVLKLIDKYDLYGQVAYPKHHKQSDVPDIYRLAAKSKGVFINPAIIEPFGLTLIEAAAHGLPMVATKNGGPVDIHRVLDNGLLVDPHDQQSISEALLKLVADKHLWAKCRQNGLKNIHQFSWPEHCKTYLSRITSFKPRHPQWQSDDGGDNSEPESPSDSLRDIQDISLNLKFSFDGSGNDNYMNQEGSSMDRKSKIEAAVQNWSKGKDSRKMGSLERSEVNSGKFPAVRRRKFIVVIALDFDGEEDTLEATKRILDAVEKERAEGSVGFILSTSLTISEVQSFLVSGGLNPNDFDAFICNSGSDLHYTSLNNEDGPFVVDFYYHSHIEYRWGGEGLRKTLIRWASSLNEKKADNDEQIVTLAEHLSTDYCYTFTVKKPAAVPPVRELRKLLRIQALRCHVVYSQNGTRINVIPVLASRIQALRYLFVRWGIDMAKMAVFVGESGDTDYEGLLGGLHKSVVLKGVSCSACLHANRSYPLTDVISFESNNVVHASPDSDVRDALKKLELLKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	QGLDDARSSPSLLLR CCHHCHHCCCHHHHH	48.61	23776212
27	Phosphorylation	GLDDARSSPSLLLRE CHHCHHCCCHHHHHH	16.98	23776212
29	Phosphorylation	DDARSSPSLLLRERG HCHHCCCHHHHHHCC	33.33	23776212
117	Phosphorylation	EKGRREATADMSEEF HHCHHHHCCCCCHHH	20.59	23776212
121	Phosphorylation	REATADMSEEFSEGE HHHCCCCCHHHCCCC	34.22	30291188
125	Phosphorylation	ADMSEEFSEGEKGDI CCCCHHHCCCCCCCC	48.23	30291188
134	Phosphorylation	GEKGDIISDISTHGE CCCCCCCCCCHHCCC	29.26	23776212
137	Phosphorylation	GDIISDISTHGESTK CCCCCCCHHCCCCCC	21.24	23776212
138	Phosphorylation	DIISDISTHGESTKP CCCCCCHHCCCCCCC	33.95	23776212
142	Phosphorylation	DISTHGESTKPRLPR CCHHCCCCCCCCCCC	46.45	23776212
143	Phosphorylation	ISTHGESTKPRLPRI CHHCCCCCCCCCCCC	40.54	23776212
152	Phosphorylation	PRLPRINSAESMELW CCCCCCCCHHHHHHH	30.92	30291188
155	Phosphorylation	PRINSAESMELWASQ CCCCCHHHHHHHHHC	19.78	24601666
161	Phosphorylation	ESMELWASQQKGNKL HHHHHHHHCCCCCEE	22.89	19376835
243	Phosphorylation	EMLTPRDSEDFSDEM CCCCCCCCCCCCHHC	40.10	23776212
247	Phosphorylation	PRDSEDFSDEMGESS CCCCCCCCHHCCCCC	45.01	23776212
418	Phosphorylation	ARIKRNVSCYGRFMP HHHHHCCCCCCCCCC	12.74	25561503
677	Phosphorylation	PRHPQWQSDDGGDNS CCCCCCCCCCCCCCC	34.41	30291188
684	Phosphorylation	SDDGGDNSEPESPSD CCCCCCCCCCCCCCC	60.30	30291188
688	Phosphorylation	GDNSEPESPSDSLRD CCCCCCCCCCCCHHH	40.18	24601666
690	Phosphorylation	NSEPESPSDSLRDIQ CCCCCCCCCCHHHHH	49.46	23776212
692	Phosphorylation	EPESPSDSLRDIQDI CCCCCCCCHHHHHEE	29.64	23776212
700	Phosphorylation	LRDIQDISLNLKFSF HHHHHEEEEEEEEEE	21.35	30291188
706	Phosphorylation	ISLNLKFSFDGSGND EEEEEEEEECCCCCC	22.35	23776212
710	Phosphorylation	LKFSFDGSGNDNYMN EEEEECCCCCCCCCC	35.95	23776212
715	Phosphorylation	DGSGNDNYMNQEGSS CCCCCCCCCCCCCCC	10.58	23776212
721	Phosphorylation	NYMNQEGSSMDRKSK CCCCCCCCCCCHHHH	23.03	23776212
722	Phosphorylation	YMNQEGSSMDRKSKI CCCCCCCCCCHHHHH	35.24	23776212
893	Phosphorylation	DNDEQIVTLAEHLST CCHHHHHHHHHHHCC	23.14	28295753
899	Phosphorylation	VTLAEHLSTDYCYTF HHHHHHHCCCEEEEE	22.57	28295753
900	Phosphorylation	TLAEHLSTDYCYTFT HHHHHHCCCEEEEEE	37.03	28295753
902	Phosphorylation	AEHLSTDYCYTFTVK HHHHCCCEEEEEEEC	6.35	28295753
904	Phosphorylation	HLSTDYCYTFTVKKP HHCCCEEEEEEECCC	9.92	28295753
905	Phosphorylation	LSTDYCYTFTVKKPA HCCCEEEEEEECCCC	14.85	28295753
907	Phosphorylation	TDYCYTFTVKKPAAV CCEEEEEEECCCCCC	24.50	28295753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPSA1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
152	S	Phosphorylation	Phosphorylated at Ser-152 upon sucrose supply.	19245862

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPSA1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPP2_ARATH	AT2G35840	physical	25873678

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.