SPRTN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPRTN_MOUSE
• UniProt AC: G3X912
• Protein Name: SprT-like domain-containing protein Spartan
• Gene Name: Sprtn
• Organism: Mus musculus (Mouse).
• Sequence Length: 497
• Subcellular Localization: Nucleus. Chromosome. Localizes to sites of UV damage via the PIP-box. Recruited to stalled replication forks at sites of replication stress (By similarity)..
• Protein Description: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity)..
• Protein Sequence: MDEDLVVALRLQEEWDVQMARRAAAAREPVSLVDASWELVDPTPDLQALFLQFNDRFFWGQLEAVEVKWSVRMTLCAGICTYEGRGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINQLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRQPYYGYVKRATNRAPSVHDYWWADHQKTCGGTYIKIKEPENYSKKGRGKTKADKQPASAVENKDKLCRGEAQLLIPFSGKGYVLGDASTCPSAGKLNTSYMVNEAKGLSSQDHSVSGLRLNSNAEVKCEQNCLPKKPHLVSPLPTASHQSVLSSYFPRVSVANQKAFRNVNGSPVKNGTTGDGTKRPASGGSQRKVPPSRASLRNTSKVTAPASATVTSAAGTSATISREESGSEDQFLNKRPRLEDRTALDTIKEQTQSGGDLRSSSQPTAASAPQSLSSQRRLVNCPVCQGVVVESQINEHLDRCLEGNKTNLRPRRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDEDLVVA -------CCHHHHEE		-
231	Acetylation	RGKTKADKQPASAVE CCCCCCCCCCCHHHC		-
269	Phosphorylation	GDASTCPSAGKLNTS ECCCCCCCCCCCCCH		-
275	Phosphorylation	PSAGKLNTSYMVNEA CCCCCCCCHHCCCCC		28576409
277	Phosphorylation	AGKLNTSYMVNEAKG CCCCCCHHCCCCCCC		28576409
286	Phosphorylation	VNEAKGLSSQDHSVS CCCCCCCCCCCCCCC		25338131
287	Phosphorylation	NEAKGLSSQDHSVSG CCCCCCCCCCCCCCC		25338131
291	Phosphorylation	GLSSQDHSVSGLRLN CCCCCCCCCCCEECC		25338131
293	Phosphorylation	SSQDHSVSGLRLNSN CCCCCCCCCEECCCC		25338131
342	Ubiquitination	RVSVANQKAFRNVNG CHHHCCCHHHCCCCC		22790023
345	Ubiquitination	VANQKAFRNVNGSPV HCCCHHHCCCCCCCC		27667366
350	Phosphorylation	AFRNVNGSPVKNGTT HHCCCCCCCCCCCCC		26745281
384	Phosphorylation	RASLRNTSKVTAPAS HHHHCCCCCCCCCCE		-
418	Ubiquitination	SEDQFLNKRPRLEDR CHHHHHHCCCCCCCH		-
432	Ubiquitination	RTALDTIKEQTQSGG HHHHHHHHHHHHCCC		22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPRTN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPRTN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPRTN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPRTN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.