SPRL1_MOUSE - dbPTM
SPRL1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPRL1_MOUSE
UniProt AC P70663
Protein Name SPARC-like protein 1
Gene Name Sparcl1
Organism Mus musculus (Mouse).
Sequence Length 650
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Protein Description
Protein Sequence MKAVLLLLCALGTAVAIPTSTRFLSDHSNPTTATLVTPEDATVPIAGVEATADIENHPSDKAEKPSALNSEEETHEQSTEQDKTYSFEVDLKDEEDGDGDLSVDPTEGTLTLDLQEGTSEPQQKSLPENGDFPATVSTSYVDPNQRANITKGKESQEQPVSDSHQQPNESSKQTQDLKAEESQTQDPDIPNEEEEEEEDEEEEEEEEPEDIGAPSDNQEEGKEPLEEQPTSKWEGNREQSDDTLEESSQPTQISKTEKHQSEQGNQGQESDSEAEGEDKAAGSKEHIPHTEQQDQEGKAGLEAIGNQKDTDEKAVSTEPTDAAVVPRSHGGAGDNGGGDDSKHGAGDDYFIPSQEFLEAERMHSLSYYLKYGGGEETTTGESENRREAADNQEAKKAESSPNAEPSDEGNSREHSAGSCTNFQCKRGHICKTDPQGKPHCVCQDPETCPPAKILDQACGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPACTDFEVAQFPLRMRDWLKNILMQLYEPNPKHGGYLNEKQRSKVKKIYLDEKRLLAGDHPIELLLRDFKKNYHMYVYPVHWQFNELDQHPADRILTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDENLLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
66PhosphorylationSDKAEKPSALNSEEE
CCCCCCCCCCCCCHH		57.3625521595
70PhosphorylationEKPSALNSEEETHEQ
CCCCCCCCCHHHHHC		47.4325521595
74PhosphorylationALNSEEETHEQSTEQ
CCCCCHHHHHCCCCC		33.7124925903
78PhosphorylationEEETHEQSTEQDKTY
CHHHHHCCCCCCCEE		30.8124925903
79PhosphorylationEETHEQSTEQDKTYS
HHHHHCCCCCCCEEE		37.0424925903
86PhosphorylationTEQDKTYSFEVDLKD
CCCCCEEEEEEECCC		21.84-
148N-linked_GlycosylationVDPNQRANITKGKES
CCCCCCCCCCCCCCC		44.65-
155PhosphorylationNITKGKESQEQPVSD
CCCCCCCCCCCCCCC		42.3725521595
161PhosphorylationESQEQPVSDSHQQPN
CCCCCCCCCCCCCCC		39.8323684622
163PhosphorylationQEQPVSDSHQQPNES
CCCCCCCCCCCCCCC		18.7125521595
168N-linked_GlycosylationSDSHQQPNESSKQTQ
CCCCCCCCCCCHHHH		58.40-
170PhosphorylationSHQQPNESSKQTQDL
CCCCCCCCCHHHHHH		49.8522817900
171PhosphorylationHQQPNESSKQTQDLK
CCCCCCCCHHHHHHH		23.7029899451
270PhosphorylationQGNQGQESDSEAEGE
CCCCCCCCCHHHCCC		38.2522324799
272PhosphorylationNQGQESDSEAEGEDK
CCCCCCCHHHCCCCC		48.2422324799
283PhosphorylationGEDKAAGSKEHIPHT
CCCCCCCCCCCCCCH		30.0921930439
290PhosphorylationSKEHIPHTEQQDQEG
CCCCCCCHHHHCHHC		30.0927742792
316PhosphorylationDTDEKAVSTEPTDAA
CCCCCCCCCCCCCEE		31.7329899451
317PhosphorylationTDEKAVSTEPTDAAV
CCCCCCCCCCCCEEE		39.1129899451
320PhosphorylationKAVSTEPTDAAVVPR
CCCCCCCCCEEEECC		31.8527357545
341PhosphorylationDNGGGDDSKHGAGDD
CCCCCCCCCCCCCCC		31.1519367708
349PhosphorylationKHGAGDDYFIPSQEF
CCCCCCCCEECCHHH		14.2427180971
353PhosphorylationGDDYFIPSQEFLEAE
CCCCEECCHHHHHHH		37.2127180971
364PhosphorylationLEAERMHSLSYYLKY
HHHHHHHHHHEEECC		15.0721183079
366PhosphorylationAERMHSLSYYLKYGG
HHHHHHHHEEECCCC		18.1021183079
368PhosphorylationRMHSLSYYLKYGGGE
HHHHHHEEECCCCCC		8.0422817900
378PhosphorylationYGGGEETTTGESENR
CCCCCCCCCCCCHHH		35.7621183079
399PhosphorylationQEAKKAESSPNAEPS
HHHHHHHCCCCCCCC		56.8220415495
400PhosphorylationEAKKAESSPNAEPSD
HHHHHHCCCCCCCCC		17.4320415495
406PhosphorylationSSPNAEPSDEGNSRE
CCCCCCCCCCCCCCC		39.5425521595
411PhosphorylationEPSDEGNSREHSAGS
CCCCCCCCCCCCCCC		50.3225521595
415PhosphorylationEGNSREHSAGSCTNF
CCCCCCCCCCCCCCC		29.5823684622
418PhosphorylationSREHSAGSCTNFQCK
CCCCCCCCCCCCEEC		19.9320415495
420PhosphorylationEHSAGSCTNFQCKRG
CCCCCCCCCCEECCC		40.5429899451
462N-linked_GlycosylationDQACGTDNQTYASSC
HHHCCCCCCHHHHHH		35.61-
501S-nitrosylationACKSIPACTDFEVAQ
CCCCCCCCCCCHHHC		2.9222588120
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPRL1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPRL1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPRL1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SPRL1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPRL1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70 AND SER-411, AND MASSSPECTROMETRY.

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