dbPTM

SPR3_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPR3_CAEEL
UniProt AC	Q17768
Protein Name	Suppressor of presenilin protein 3
Gene Name	spr-3
Organism	Caenorhabditis elegans.
Sequence Length	684
Subcellular Localization	Nucleus .
Protein Description	Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1..
Protein Sequence	MPPRKRKLEELKNEQGEQGSYKCHLCGQCFYRGCGLASHLRRHAPVTFDCEHCAYTCKHKYAYDRHLLQSHPELVESGPLVRMFKNEDEDAPMPILEREADVSDDAVKYEALSSFSEPEPISYKCPLCISTFGSHARAVYHILSHRVKLYQAPKSLKFFSRKTMQALGGFRLESQLMIKWRLQYDNRSVDEKRTRLWRYMEENFGHEHLKQPKLESDNPSTSSSFESQTNLNDSSIIKKKLVMKCGTVFGQRLIHDNTQYYLCRNCPYVSWNVSSLWRHFRHHIQKSKQSWTCIACSYSSSSRVKIDLHVKMHKEMPEIDLEFATWLRYERRINKNDLNKPTNKKKKPDGGNGSNHSDMRSLHAFLSLKNSKNNVVKHDIDAPTLHPLSPAPKLVAMTQFDFGEIVTYKSVNPLHQINKNNSNPTVLPNKRNSIKTSKSDTQIALSVKQSSSMKMVKVSPGKVYQLPKTSKFYRPESPDSLASNNSAHGDEIESTSSDQFQQSVKVPKYEDFLNMKPVMPYFQKQRHPLEAIAMYEKAKREYEKNHCFPNLPIFEFNIEYKNLHPLAKAQYGKNNMKEYFLNEMEVEKSRECTDCPFKHNDLQQFRLHRDKHFYGGSHTCPECNYSSNNHNQVVEHTFVDHYLSDVRLVEGLPSSDSEDDNIPVPPDTPQRKKKAPKRGKRRGW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Phosphorylation	LEREADVSDDAVKYE EEEECCCCCHHHHHH	30.25	30078680
184	Phosphorylation	MIKWRLQYDNRSVDE EEEEECCCCCCCHHH	21.56	19530675
188	Phosphorylation	RLQYDNRSVDEKRTR ECCCCCCCHHHHHHH	39.93	19530675
389	Phosphorylation	APTLHPLSPAPKLVA CCCCCCCCCCCCEEE	24.38	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPR3_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPR3_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPR3_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SPR3_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPR3_CAEEL

Related Literatures of Post-Translational Modification