SPR1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPR1A_HUMAN
• UniProt AC: P35321
• Protein Name: Cornifin-A
• Gene Name: SPRR1A
• Organism: Homo sapiens (Human).
• Sequence Length: 89
• Subcellular Localization: Cytoplasm.
• Protein Description: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane..
• Protein Sequence: MNSQQQKQPCTPPPQPQQQQVKQPCQPPPQEPCIPKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCQPKVPEPCPSTVTPAPAQQKTKQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MNSQQQKQPC -----CCHHHHCCCC	28.24	27135362
11	Phosphorylation	QQQKQPCTPPPQPQQ HHHCCCCCCCCCCCH	45.58	26657352
41	S-nitrosylation	IPKTKEPCHPKVPEP CCCCCCCCCCCCCCC	10.08	24105792
49	S-nitrosylation	HPKVPEPCHPKVPEP CCCCCCCCCCCCCCC	9.05	24105792
57	S-nitrosylation	HPKVPEPCQPKVPEP CCCCCCCCCCCCCCC	11.74	24105792
68	Methylation	VPEPCQPKVPEPCPS CCCCCCCCCCCCCCC	44.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPR1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPR1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPR1A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPR1A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.