SPOC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPOC1_HUMAN
• UniProt AC: Q6ZMY3
• Protein Name: SPOC domain-containing protein 1
• Gene Name: SPOCD1
• Organism: Homo sapiens (Human).
• Sequence Length: 1216
• Protein Sequence: MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRPREARDGGMSSPGCDRRSPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKEPCRLPASKMTHKGEVEIQRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQHDHHFLDPNCHICKDWEPSNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELSPTEPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASICPAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLASVEHMGMVLLPLPAFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGLPDTAGSSPWLGKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAPRGISAWQRPPRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFHRDSCPHQALLRHLESLATMSHQLQALLCPQTKSSIPRPLQRLSSALAAPEPPGPARDSSLGPTDEAGSECPFPRKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Methylation	IPRKEALRGGSSRAA CCHHHHHCCCCCCCC	55.25	115917593
216	Phosphorylation	WRRQGAHSECEEGAG HHHCCCCCCCCCCCC	43.33	28387310
231	Phosphorylation	DFLWLDQSPRGDNLL CEEEECCCCCCCCCC	19.07	28387310
251	Phosphorylation	PQVADLESLGGPCRP CCCCCHHHCCCCCCC	39.34	28348404
260	Phosphorylation	GGPCRPPSPKDTGSG CCCCCCCCCCCCCCC	47.46	28348404
274	Phosphorylation	GPGEPGGSGAGCASG CCCCCCCCCCCCCCC	31.24	-
410	Phosphorylation	TEASRACSGPFMEQR HHHHHHCCCHHHHHH	48.82	-
511	Phosphorylation	LEDLMEVSSPSPAQR HHHHHHHCCCCHHHH	24.19	30206219
512	Phosphorylation	EDLMEVSSPSPAQRL HHHHHHCCCCHHHHH	34.27	30206219
514	Phosphorylation	LMEVSSPSPAQRLRR HHHHCCCCHHHHHHH	34.51	30206219
622	Phosphorylation	SMQEVLWTRLRELPD HHHHHHHHHHHHCCC	18.70	17081983
1077	Phosphorylation	QQSQGRGSIAPRGIS CCCCCCCCCCCCCCC	17.76	24719451
1135	Methylation	PAGHGFGRGQHFHRD CCCCCCCCCCCCCCC	39.06	115917585
1141	Methylation	GRGQHFHRDSCPHQA CCCCCCCCCCCHHHH	36.27	115917589
1183	Phosphorylation	PRPLQRLSSALAAPE CHHHHHHHHHHHCCC	18.76	27251275
1184	Phosphorylation	RPLQRLSSALAAPEP HHHHHHHHHHHCCCC	31.71	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPOC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPOC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPOC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPOC1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.