SPN90_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPN90_MOUSE
• UniProt AC: Q9ESJ4
• Protein Name: NCK-interacting protein with SH3 domain
• Gene Name: Nckipsd
• Organism: Mus musculus (Mouse).
• Sequence Length: 714
• Subcellular Localization: Nucleus. Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes..
• Protein Description: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1) (By similarity). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomere and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion..
• Protein Sequence: MYRALYAFRSAEPNAMAFAAGETFLVLERSSTHWWLAARARSGETGYVPPAYLHRLQGMEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGTSASSATVMTPSTSDHHLDAAVSRQPNGVCRTGFERQHSLPSSEHLGTDGALYQVPPQPRRAAPTTPPPPVKRRDREALVISGSGGRTAIPSGGSSVSSGSSASSTSMDTLYTGSSPSELGPSCSPTPPPVPRRGAHTTVSQPQPSPSKAPSPEPPTEEVAAETNSTPDDLEAQDALSPETTEEKAAAETVVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHIQATVPASSPIMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEDVIRCYLEELLHILTDADPEVCKKMCKRSDFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALVLAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVEDGLPMDTTEQLPDLCMNLLLALNLHLTAPEQNVIMAALSRHTNVKIFSEKLLLLLNRGDDPVRIFRHEPQPPHSVLKFLQDVFSSSATAAIFYHTDMMALIDITVRQIADLSPGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDLQATLRRILTEEEASPQCQMDRMIVQEMYKEFPDLGEVPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MYRALYAFRSAEP --CCHHHHHHHCCCC	11.60	28059163
10	Phosphorylation	RALYAFRSAEPNAMA HHHHHHHCCCCCEEE	30.45	28059163
32	Phosphorylation	LVLERSSTHWWLAAR EEEECCCCHHEEEHH	23.82	22807455
105	Phosphorylation	HHRKETLSRRGTSAS HHHHHHHHHCCCCCC	27.61	23140645
110	Phosphorylation	TLSRRGTSASSATVM HHHHCCCCCCCCEEE	29.04	29472430
115	Phosphorylation	GTSASSATVMTPSTS CCCCCCCEEECCCCC	16.86	29472430
118	Phosphorylation	ASSATVMTPSTSDHH CCCCEEECCCCCCCC	15.11	29899451
120	Phosphorylation	SATVMTPSTSDHHLD CCEEECCCCCCCCHH	31.23	22817900
121	Phosphorylation	ATVMTPSTSDHHLDA CEEECCCCCCCCHHH	39.10	29472430
122	Phosphorylation	TVMTPSTSDHHLDAA EEECCCCCCCCHHHH	39.01	19060867
131	Phosphorylation	HHLDAAVSRQPNGVC CCHHHHHHCCCCCCC	22.07	29472430
147	Phosphorylation	TGFERQHSLPSSEHL CCCCCCCCCCCCCCC	33.37	27180971
150	Phosphorylation	ERQHSLPSSEHLGTD CCCCCCCCCCCCCCC	54.36	22499769
151	Phosphorylation	RQHSLPSSEHLGTDG CCCCCCCCCCCCCCC	27.39	22499769
156	Phosphorylation	PSSEHLGTDGALYQV CCCCCCCCCCCCEEC	37.31	22499769
161	Phosphorylation	LGTDGALYQVPPQPR CCCCCCCEECCCCCC	13.61	22499769
173	Phosphorylation	QPRRAAPTTPPPPVK CCCCCCCCCCCCCCC	47.40	25521595
174	Phosphorylation	PRRAAPTTPPPPVKR CCCCCCCCCCCCCCC	32.51	25521595
190	Phosphorylation	DREALVISGSGGRTA CCCEEEECCCCCCCC	21.30	21454597
192	Phosphorylation	EALVISGSGGRTAIP CEEEECCCCCCCCCC	31.14	21454597
249	Phosphorylation	RGAHTTVSQPQPSPS CCCCCCCCCCCCCCC	33.77	28066266
254	Phosphorylation	TVSQPQPSPSKAPSP CCCCCCCCCCCCCCC	36.24	22324799
256	Phosphorylation	SQPQPSPSKAPSPEP CCCCCCCCCCCCCCC	45.87	29899451
260	Phosphorylation	PSPSKAPSPEPPTEE CCCCCCCCCCCCHHH	46.91	25521595
265	Phosphorylation	APSPEPPTEEVAAET CCCCCCCHHHHHHHC	56.33	26643407
272	Phosphorylation	TEEVAAETNSTPDDL HHHHHHHCCCCCCHH	29.73	25777480
274	Phosphorylation	EVAAETNSTPDDLEA HHHHHCCCCCCHHHH	49.05	19060867
275	Phosphorylation	VAAETNSTPDDLEAQ HHHHCCCCCCHHHHH	32.57	25521595
286	Phosphorylation	LEAQDALSPETTEEK HHHHHHCCCCCHHHH	23.55	25521595
289	Phosphorylation	QDALSPETTEEKAAA HHHCCCCCHHHHHHH	42.78	21183079
290	Phosphorylation	DALSPETTEEKAAAE HHCCCCCHHHHHHHH	40.25	25777480
505	Phosphorylation	LVLAMVFSMGEAVPY HHHHHHHHCCCCCCH	17.92	-
512	Phosphorylation	SMGEAVPYAHYEHLG HCCCCCCHHHHHHCC	10.22	-
615	Phosphorylation	KFLQDVFSSSATAAI HHHHHHHCCCCCHHH	24.19	-
616	Phosphorylation	FLQDVFSSSATAAIF HHHHHHCCCCCHHHH	16.72	-
643	Phosphorylation	VRQIADLSPGDKLRM HHHHHCCCCCCHHHH	27.64	-
652	Phosphorylation	GDKLRMEYLSLMHAV CCHHHHHHHHHHHHH	7.70	21454597
654	Phosphorylation	KLRMEYLSLMHAVVR HHHHHHHHHHHHHHH	23.81	21454597
662	Phosphorylation	LMHAVVRSTPYLQHR HHHHHHHCCHHHHHH	23.32	21454597
663	Phosphorylation	MHAVVRSTPYLQHRH HHHHHHCCHHHHHHH	12.85	21454597
665	Phosphorylation	AVVRSTPYLQHRHRL HHHHCCHHHHHHHHH	21.05	21454597
673	Phosphorylation	LQHRHRLSDLQATLR HHHHHHHHHHHHHHH	35.91	22817900
678	Phosphorylation	RLSDLQATLRRILTE HHHHHHHHHHHHHCC	14.08	22006019
684	Phosphorylation	ATLRRILTEEEASPQ HHHHHHHCCHHCCCC	38.69	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPN90_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPN90_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPN90_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPN90_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.