| UniProt ID | SPIDR_HUMAN | |
|---|---|---|
| UniProt AC | Q14159 | |
| Protein Name | DNA repair-scaffolding protein | |
| Gene Name | SPIDR | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 915 | |
| Subcellular Localization | Nucleus . Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. | |
| Protein Description | Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.. | |
| Protein Sequence | MPRGSRARGSKRKRSWNTECPSFPGERPLQVRRAGLRTAGAAASLSEAWLRCGEGFQNTSGNPSLTAEEKTITEKHLELCPRPKQETTTSKSTSGLTDITWSSSGSDLSDEDKTLSQLQRDELQFIDWEIDSDRAEASDCDEFEDDEGAVEISDCASCASNQSLTSDEKLSELPKPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIGLEEIELLSAGGASAEH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | RGSKRKRSWNTECPS CCCCCCCCCCCCCCC | 28450419 | ||
| 18 | Phosphorylation | KRKRSWNTECPSFPG CCCCCCCCCCCCCCC | 28450419 | ||
| 84 | Sumoylation | LELCPRPKQETTTSK HHCCCCCCCCCCCCC | - | ||
| 84 | Sumoylation | LELCPRPKQETTTSK HHCCCCCCCCCCCCC | - | ||
| 88 | Phosphorylation | PRPKQETTTSKSTSG CCCCCCCCCCCCCCC | - | ||
| 102 | Phosphorylation | GLTDITWSSSGSDLS CCEEEEECCCCCCCC | 27251275 | ||
| 103 | Phosphorylation | LTDITWSSSGSDLSD CEEEEECCCCCCCCH | 27251275 | ||
| 104 | Phosphorylation | TDITWSSSGSDLSDE EEEEECCCCCCCCHH | 27251275 | ||
| 106 | Phosphorylation | ITWSSSGSDLSDEDK EEECCCCCCCCHHHH | 27251275 | ||
| 109 | Phosphorylation | SSSGSDLSDEDKTLS CCCCCCCCHHHHHHH | 27251275 | ||
| 132 | Phosphorylation | FIDWEIDSDRAEASD HCCEEECCCCCCHHC | 27499020 | ||
| 153 | Phosphorylation | DEGAVEISDCASCAS CCCCEEHHHHHHHHC | - | ||
| 166 | Phosphorylation | ASNQSLTSDEKLSEL HCCCCCCCCHHHHCC | 26657352 | ||
| 171 | Phosphorylation | LTSDEKLSELPKPSS CCCCHHHHCCCCCCC | 26657352 | ||
| 204 | Phosphorylation | VLLIDSESPHKYHVQ EEEECCCCCCCEEEE | 25849741 | ||
| 225 | Ubiquitination | QIMERLIDPRTKSTE HHHHHHCCCCCCCCC | 29967540 | ||
| 230 | Phosphorylation | LIDPRTKSTETILHT HCCCCCCCCCEEECC | 23312004 | ||
| 231 | Phosphorylation | IDPRTKSTETILHTP CCCCCCCCCEEECCC | 23312004 | ||
| 233 | Phosphorylation | PRTKSTETILHTPQK CCCCCCCEEECCCCC | 23312004 | ||
| 235 | Ubiquitination | TKSTETILHTPQKPT CCCCCEEECCCCCCC | 29967540 | ||
| 237 | Phosphorylation | STETILHTPQKPTAK CCCEEECCCCCCCCC | 20068231 | ||
| 242 | Phosphorylation | LHTPQKPTAKFPRTP ECCCCCCCCCCCCCC | 23898821 | ||
| 248 | Phosphorylation | PTAKFPRTPENSAKK CCCCCCCCCCCHHHH | 28985074 | ||
| 252 | Phosphorylation | FPRTPENSAKKKLLR CCCCCCCHHHHHHHH | 22210691 | ||
| 259 | Methylation | SAKKKLLRGGLAERL HHHHHHHHHHHHHHH | 115917577 | ||
| 276 | Ubiquitination | LQNRERSAISLWRHQ CCCCHHHHHHHHHHH | 29967540 | ||
| 276 | Ubiquitination | LQNRERSAISLWRHQ CCCCHHHHHHHHHHH | - | ||
| 278 | Phosphorylation | NRERSAISLWRHQCI CCHHHHHHHHHHHHH | 24719451 | ||
| 286 | Ubiquitination | LWRHQCISYQKTLSG HHHHHHHHHHHHHCC | 29967540 | ||
| 287 | Phosphorylation | WRHQCISYQKTLSGR HHHHHHHHHHHHCCC | - | ||
| 295 | Ubiquitination | QKTLSGRKSGVLTVK HHHHCCCCCEEEEEE | 29967540 | ||
| 326 | Ubiquitination | QLLGSPATSSSQSVA HHHCCCCCCCCCCCC | 29967540 | ||
| 336 | Ubiquitination | SQSVAPRPGAGLKVL CCCCCCCCCCCEEEE | 29967540 | ||
| 346 | Ubiquitination | GLKVLFTKETAGYLR CEEEEEECCCCHHHC | 29967540 | ||
| 396 | Ubiquitination | VAKEDSEKTCEVYCP EECCCCCCCEEEECC | 29967540 | ||
| 457 | Phosphorylation | EAKQRIPTSTPLRDS HHHHHCCCCCCHHHH | 28302921 | ||
| 458 | Phosphorylation | AKQRIPTSTPLRDSL HHHHCCCCCCHHHHH | 24719451 | ||
| 459 | Phosphorylation | KQRIPTSTPLRDSLL HHHCCCCCCHHHHHH | 28302921 | ||
| 464 | Phosphorylation | TSTPLRDSLLDVVES CCCCHHHHHHHHHHH | 28302921 | ||
| 475 | Ubiquitination | VVESQGAASWPGAGV HHHHCCCCCCCCCCE | 29967540 | ||
| 485 | Ubiquitination | PGAGVRVVVQRVYSL CCCCEEEEEEEEEEC | 29967540 | ||
| 490 | Phosphorylation | RVVVQRVYSLPSRDS EEEEEEEEECCCCCC | 26437602 | ||
| 491 | Phosphorylation | VVVQRVYSLPSRDST EEEEEEEECCCCCCC | 26437602 | ||
| 494 | Phosphorylation | QRVYSLPSRDSTRGQ EEEEECCCCCCCCCC | 26437602 | ||
| 497 | Phosphorylation | YSLPSRDSTRGQQGA EECCCCCCCCCCCCC | 30576142 | ||
| 498 | Phosphorylation | SLPSRDSTRGQQGAS ECCCCCCCCCCCCCC | 30576142 | ||
| 509 | Phosphorylation | QGASSGHTDPAGTRA CCCCCCCCCCCHHHH | 30576142 | ||
| 514 | Phosphorylation | GHTDPAGTRACLLVQ CCCCCCHHHHHHHHH | - | ||
| 545 | Ubiquitination | KARQLEGKSCSLVGM HHHHHCCCCCCHHHH | 29967540 | ||
| 557 | Ubiquitination | VGMKVLQKVTRGRTA HHHHHHHHHHCCCCC | - | ||
| 559 | Phosphorylation | MKVLQKVTRGRTAGI HHHHHHHHCCCCCCH | - | ||
| 572 | Phosphorylation | GIFSLIDTLWPPAIP CHHHHHHHHCCCCCC | - | ||
| 582 | Phosphorylation | PPAIPLKTPGRDQPC CCCCCCCCCCCCCCH | - | ||
| 594 | Phosphorylation | QPCEEIKTHLPPPAL CCHHHHHHCCCCCCE | - | ||
| 603 | Phosphorylation | LPPPALCYILTAHPN CCCCCEEEEEECCCC | - | ||
| 606 | Phosphorylation | PALCYILTAHPNLGQ CCEEEEEECCCCCCC | - | ||
| 623 | Phosphorylation | IIDEDPIYKLYQPPV CCCCCCCHHHHCCCH | - | ||
| 646 | Methylation | QMNDLGTRCSFYATV HCCCCCCCCEEEEEE | 54556999 | ||
| 803 | Ubiquitination | VCDMCGNGRLEQRPE CHHCCCCCCCCCCCC | 29967540 | ||
| 825 | Phosphorylation | GDCSRVVTSPVLKRH CCCCCEECCHHHHHH | 29396449 | ||
| 826 | Phosphorylation | DCSRVVTSPVLKRHL CCCCEECCHHHHHHH | 28985074 | ||
| 857 | Phosphorylation | KLLQRSISSLLRFAA HHHHHHHHHHHHHHH | 30624053 | ||
| 858 | Phosphorylation | LLQRSISSLLRFAAG HHHHHHHHHHHHHHC | 24719451 | ||
| 873 | Ubiquitination | EDGSYEVKSVLGKEV CCCCEEHHHHCCCCH | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPIDR_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPIDR_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPIDR_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SPIDR_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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