SPICE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPICE_MOUSE
• UniProt AC: Q8C804
• Protein Name: Spindle and centriole-associated protein 1
• Gene Name: Spice1
• Organism: Mus musculus (Mouse).
• Sequence Length: 860
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle.
• Protein Description: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis..
• Protein Sequence: MSLIRVNRFGPRGGGRKTLKVKKKAAVRQEWDNTVNDLTVHRATPEDLVRRHEMHKSKNRALVHWELQEKALKRKWKKQKPETSSLEKRKLSIMKEILSDQYLTQDVLEKSDHLMAAAKGLFADVPRKRTGFPNVTRAPDSSQSHTGINQDPVTQSILNESIIEPQALNEVDDAGEQSTAHSQSEDSENELPNSLSQHSNRSTERFLHQLKEENSELINQLWTDIQQKIATQSQRTPPGSPSSELSAEDQKAALNATDAVKRIQAGPQPEEAAEPVDFSSSYLGQVLNTRKQKPLLAKVKRKQDMHAASKQKTNMLSSSTASADRPSSTGSSLDVLKHVIHEVEHEMEEYERCTGREVTGLQGGQGLTGFTLSLVSSLCRLVRYLKESEIQLRKEVETRQQLEQMLGDHRELIDALTAEILSLREENSTMQARLQQYMVTTDEQLISLTHAIKNCPVINNSRQESQAPERAAMGRRLVDNVEGPVISSNGSMPLMFRGEEVVEFPQEELPVKLSQGPTPTENLNLANNFPTHIFEPAVMLTPPRQKSNSEFSPLQDVLRRTVQTRPAPRIPPTVEVIEKEQNWEKKALPIDPDIQNSSEENRLFTQRWRVSHMGEDLENKGQPAFVSLSQPPCSSLPSTQQPRNPVLSEEPTVLGDGQQLRTSEALVQRKDIMARIAELTLQNSAIKAHLNNITSSGGEQGDGLREPRKQGSASEVSTNFPAVQSLTPSSMEERIAELNRQSMEARSKLLQLIEQQKLVGLNLSSSPVSPVESPLRAWAEEGKRTIEVSVPGMEASESSKCNTVSPVSGNSSRRSSGAISNSCSPLNATSGSGKFTPVNPRTKTEKKNEEGWFALSAHIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLIRVNRF ------CCCEECCCC	32.29	29514104
44	Phosphorylation	DLTVHRATPEDLVRR HHHCCCCCHHHHHHH	27.45	22817900
83	Phosphorylation	WKKQKPETSSLEKRK HHHCCCCCCHHHHHH	31.95	22871156
84	Phosphorylation	KKQKPETSSLEKRKL HHCCCCCCHHHHHHH	31.12	22871156
85	Phosphorylation	KQKPETSSLEKRKLS HCCCCCCHHHHHHHH	48.22	28285833
92	Phosphorylation	SLEKRKLSIMKEILS HHHHHHHHHHHHHHC	24.54	24453211
231	Phosphorylation	DIQQKIATQSQRTPP HHHHHHHHHCCCCCC	32.02	23608596
233	Phosphorylation	QQKIATQSQRTPPGS HHHHHHHCCCCCCCC	19.78	21183079
236	Phosphorylation	IATQSQRTPPGSPSS HHHHCCCCCCCCCCH	26.63	21082442
240	Phosphorylation	SQRTPPGSPSSELSA CCCCCCCCCCHHCCH	27.64	26824392
242	Phosphorylation	RTPPGSPSSELSAED CCCCCCCCHHCCHHH	37.84	21183079
243	Phosphorylation	TPPGSPSSELSAEDQ CCCCCCCHHCCHHHH	46.04	19060867
246	Phosphorylation	GSPSSELSAEDQKAA CCCCHHCCHHHHHHH	26.09	23608596
313	Phosphorylation	HAASKQKTNMLSSST HHHHHHHHCCCCCCC	24.30	25293948
317	Phosphorylation	KQKTNMLSSSTASAD HHHHCCCCCCCCCCC	16.09	25293948
318	Phosphorylation	QKTNMLSSSTASADR HHHCCCCCCCCCCCC	27.96	25293948
319	Phosphorylation	KTNMLSSSTASADRP HHCCCCCCCCCCCCC	25.31	25293948
320	Phosphorylation	TNMLSSSTASADRPS HCCCCCCCCCCCCCC	26.95	25293948
322	Phosphorylation	MLSSSTASADRPSST CCCCCCCCCCCCCCC	30.69	25293948
422	Phosphorylation	ALTAEILSLREENST HHHHHHHHHHHCCHH	30.92	23737553
541	Phosphorylation	FEPAVMLTPPRQKSN CCCEEECCCCCCCCC	17.10	28285833
547	Phosphorylation	LTPPRQKSNSEFSPL CCCCCCCCCCCCCHH	36.93	26745281
549	Phosphorylation	PPRQKSNSEFSPLQD CCCCCCCCCCCHHHH	47.30	28066266
552	Phosphorylation	QKSNSEFSPLQDVLR CCCCCCCCHHHHHHH	22.20	28066266
648	Phosphorylation	QPRNPVLSEEPTVLG CCCCCCCCCCCCCCC	39.90	29899451
680	Phosphorylation	MARIAELTLQNSAIK HHHHHHHHHCCHHHH	20.15	28066266
684	Phosphorylation	AELTLQNSAIKAHLN HHHHHCCHHHHHHHH	20.57	28066266
712	Phosphorylation	REPRKQGSASEVSTN CCCCCCCCHHHCCCC	26.57	28285833
714	Phosphorylation	PRKQGSASEVSTNFP CCCCCCHHHCCCCCC	39.98	28285833
764	Phosphorylation	KLVGLNLSSSPVSPV CCCCCCCCCCCCCCC	27.91	21082442
765	Phosphorylation	LVGLNLSSSPVSPVE CCCCCCCCCCCCCCC	41.65	21082442
766	Phosphorylation	VGLNLSSSPVSPVES CCCCCCCCCCCCCCC	26.41	26824392
769	Phosphorylation	NLSSSPVSPVESPLR CCCCCCCCCCCCHHH	26.98	26824392
773	Phosphorylation	SPVSPVESPLRAWAE CCCCCCCCHHHHHHH	29.48	23984901
785	Phosphorylation	WAEEGKRTIEVSVPG HHHCCCCEEEEECCC	25.60	25777480
789	Phosphorylation	GKRTIEVSVPGMEAS CCCEEEEECCCCCCC	15.14	25777480
796	Phosphorylation	SVPGMEASESSKCNT ECCCCCCCCCCCCCC	25.38	25777480
798	Phosphorylation	PGMEASESSKCNTVS CCCCCCCCCCCCCCC	32.38	25777480
799	Phosphorylation	GMEASESSKCNTVSP CCCCCCCCCCCCCCC	36.86	25777480
805	Phosphorylation	SSKCNTVSPVSGNSS CCCCCCCCCCCCCCC	19.97	27841257
808	Phosphorylation	CNTVSPVSGNSSRRS CCCCCCCCCCCCCCC	35.32	22871156
811	Phosphorylation	VSPVSGNSSRRSSGA CCCCCCCCCCCCCCC	28.84	22871156
812	Phosphorylation	SPVSGNSSRRSSGAI CCCCCCCCCCCCCCC	35.39	22871156
815	Phosphorylation	SGNSSRRSSGAISNS CCCCCCCCCCCCCCC	31.82	25619855
816	Phosphorylation	GNSSRRSSGAISNSC CCCCCCCCCCCCCCC	30.36	25619855
820	Phosphorylation	RRSSGAISNSCSPLN CCCCCCCCCCCCCCC	23.35	25619855
824	Phosphorylation	GAISNSCSPLNATSG CCCCCCCCCCCCCCC	32.04	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPICE_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPICE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPICE_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPICE_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.