SPI2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPI2A_HUMAN
• UniProt AC: Q99865
• Protein Name: Spindlin-2A
• Gene Name: SPIN2A
• Organism: Homo sapiens (Human).
• Sequence Length: 258
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity. [PubMed: 29061846]
• Protein Sequence: MKTPNAQEAEGQQTRAAAGRATGSANMTKKKVSQKKQRGRPSSQPRRNIVGCRISHGWKEGDEPITQWKGTVLDQVPINPSLYLVKYDGIDCVYGLELHRDERVLSLKILSDRVASSHISDANLANTIIGKAVEHMFEGEHGSKDEWRGMVLAQAPIMKAWFYITYEKDPVLYMYQLLDDYKEGDLRIMPESSESPPTEREPGGVVDGLIGKHVEYTKEDGSKRIGMVIHQVETKPSVYFIKFDDDFHIYVYDLVKKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MKTPNAQEA ------CCCCCHHHH	73.09	-
3	Phosphorylation	-----MKTPNAQEAE -----CCCCCHHHHC	22.07	21815630
3	O-linked_Glycosylation	-----MKTPNAQEAE -----CCCCCHHHHC	22.07	30620550
14	Phosphorylation	QEAEGQQTRAAAGRA HHHCCHHHHHHHHHC	17.87	24043423
87	Phosphorylation	PSLYLVKYDGIDCVY CCEEEEEECCCCEEE	16.36	-
94	Phosphorylation	YDGIDCVYGLELHRD ECCCCEEEEEEECCC	23.48	-
106	Phosphorylation	HRDERVLSLKILSDR CCCCCEEEEEECHHH	25.43	24719451
108	Ubiquitination	DERVLSLKILSDRVA CCCEEEEEECHHHHH	37.92	21890473
116	Phosphorylation	ILSDRVASSHISDAN ECHHHHHHCCCCHHH	21.42	20068231
117	Phosphorylation	LSDRVASSHISDANL CHHHHHHCCCCHHHH	18.33	20068231
120	Phosphorylation	RVASSHISDANLANT HHHHCCCCHHHHHHH	25.83	20068231
127	Phosphorylation	SDANLANTIIGKAVE CHHHHHHHHHHHHHH	14.36	20068231
143	Phosphorylation	MFEGEHGSKDEWRGM HHCCCCCCCCHHHCE	38.55	-
144	Ubiquitination	FEGEHGSKDEWRGMV HCCCCCCCCHHHCEE	65.35	-
182	Ubiquitination	YQLLDDYKEGDLRIM EEECHHHHCCCEEEC	63.31	-
192	Phosphorylation	DLRIMPESSESPPTE CEEECCCCCCCCCCC	33.27	27732954
193	Phosphorylation	LRIMPESSESPPTER EEECCCCCCCCCCCC	40.19	24719451
195	Phosphorylation	IMPESSESPPTEREP ECCCCCCCCCCCCCC	37.82	21815630
198	Phosphorylation	ESSESPPTEREPGGV CCCCCCCCCCCCCCC	51.57	27732954
212	Ubiquitination	VVDGLIGKHVEYTKE CCCCCCEEEEEEECC	37.17	-
234	Phosphorylation	MVIHQVETKPSVYFI EEEEEEECCCEEEEE	49.77	20068231
237	Phosphorylation	HQVETKPSVYFIKFD EEEECCCEEEEEEEC	30.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPI2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPI2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPI2A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPI2A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.