SPG17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPG17_HUMAN
• UniProt AC: Q6Q759
• Protein Name: Sperm-associated antigen 17
• Gene Name: SPAG17
• Organism: Homo sapiens (Human).
• Sequence Length: 2223
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, flagellum axoneme . Detected in the cytoplasm of round spermatids and in condensing spermatids. Localized to the central pair of the sperm flagellar axoneme. Colocalizes with SPAG6 on microtubules (By similarity).
• Protein Description: Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts..
• Protein Sequence: MAPKKEKGGTVNTSSKIWEPSLIAAQFNQNDWQASIAFVVGNQIEDDLLIQALTVAVQVPQRKLFSMVSWQDILQQINEINTLVGSASSKKAKKPVGGNAPLYYEVLTAAKAIMDSGEKLTLPLIGKLLKFQLLQIKFKDQQRRENEKKVIEDKPKLEKDKGKAKSPKEKKAPSAKPAKGKGKDQPEANAPVKKTTQLKRRGEDDHTNRYIDDEPDDGAQHYIIVVGFNNPQLLAIMAELGIPITSVIKISSENYEPLQTHLAAVNQQQEVLLQSEDLEAEKLKKENAIKELKTFWKYLEPVLNNEKPETNLFDVARLEYMVKAADFPSDWSDGEMMLKLGTDIFENIACLMYDILDWKRQHQHYLESMQLINVPQVVNEKPVLEAMPTSEAPQPAVPAPGKKKAQYEEPQAPPPVTSVITTEVDMRYYNYLLNPIREEFISVPLILHCMLEQVVATEEDLVPPSLREPSPRADGLDHRIAAHIVSLLPSLCLSEREKKNLHDIFLSEEENESKAVPKGPLLLNYHDAHAHKKYALQDQKNFDPVQIEQEMQSKLPLWEFLQFPLPPPWNNTKRLATIHELMHFCTSDVLSWNEVERAFKVFTFESLKLSEVDEKGKLKPSGMMCGSDSEMFNIPWDNPARFAKQIRQQYVMKMNTQEAKQKADIKIKDRTLFVDQNLSMSVQDNESNREPSDPSQCDANNMKHSDLNNLKLSVPDNRQLLEQESIMKAQPQHESLEQTTNNEIKDDAVTKADSHEKKPKKMMVEADLEDIKKTQQRSLMDWSFTEHFKPKVLLQVLQEAHKQYRCVDSYYHTQDNSLLLVFHNPMNRQRLHCEYWNIALHSNVGFRNYLELVAKSIQDWITKEEAIYQESKMNEKIIRTRAELELKSSANAKLTSASKIFSIKESKSNKGISKTEISDQEKEKEKEKIPFILEGSLKAWKEEQHRLAEEERLREEKKAEKKGKEAGKKKGKDNAEKEDSRSLKKKSPYKEKSKEEQVKIQEVTEESPHQPEPKITYPFHGYNMGNIPTQISGSNYYLYPSDGGQIEVEKTMFEKGPTFIKVRVVKDNHNFMIHLNDPKEIVKKEEKGDYYLEEEEEGDEEQSLETEVSDAKNKAFSKFGSFSATLENGICLSISYYGSNGMAPEDKDPDLETILNIPSALTPTVVPVIVTVPQSKAKGKIKGKEKPKESLKEEEHPKEEEKKEEEVEPEPVLQETLDVPTFQSLNVSCPSGLLLTFIGQESTGQYVIDEEPTWDIMVRQSYPQRVKHYEFYKTVMPPAEQEASRVITSQGTVVKYMLDGSTQILFADGAVSRSPNSGLICPPSEMPATPHSGDLMDSISQQKSETIPSEITNTKKGKSHKSQSSMAHKGEIHDPPPEAVQTVTPVEVHIGTWFTTTPEGNRIGTKGLERIADLTPLLSFQATDPVNGTVMTTREDKVVIVERKDGTRIVDHADGTRITTFYQVYEDQIILPDDQETTEGPRTVTRQVKCMRVESSRYATVIANCEDSSCCATFGDGTTIIAKPQGTYQVLPPNTGSLYIDKDCSAVYCHESSSNIYYPFQKREQLRAGRYIMRHTSEVICEVLDPEGNTFQVMADGSISTILPEKKLEDDLNEKTEGYDSLSSMHLEKNHQQIYGEHVPRFFVMYADGSGMELLRDSDIEEYLSLAYKESNTVVLQEPVQEQPGTLTITVLRPFHEASPWQVKKEDTIVPPNLRSRSWETFPSVEKKTPGPPFGTQIWKGLCIESKQLVSAPGAILKSPSVLQMRQFIQHEVIKNEVKLRLQVSLKDYINYILKKEDELQEMMVKDSRTEEERGNAADLLKLVMSFPKMEETTKSHVTEVAAHLTDLFKQSLATPPKCPPDTFGKDFFEKTWRHTASSKRWKEKIDKTRKEIETTQNYLMDIKNRIIPPFFKSELNQLYQSQYNHLDSLSKKLPSFTKKNEDANETAVQDTSDLNLDFKPHKVSEQKSSSVPSLPKPEISADKKDFTAQNQTENLTKSPEEAESYEPVKIPTQSLLQDVAGQTRKEKVKLPHYLLSSKPKSQPLAKVQDSVGGKVNTSSVASAAINNAKSSLFGFHLLPSSVKFGVLKEGHTYATVVKLKNVGVDFCRFKVKQPPPSTGLKVTYKPGPVAAGMQTELNIELFATAVGEDGAKGSAHISHNIEIMTEHEVLFLPVEATVLTSSNYDKRPKDFPQGKENPMVQRTSTIYSSTLGVFMSRKVSPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	PKKEKGGTVNTSSKI CCCCCCCCCCCCCCC	21.17	-
66	Phosphorylation	VPQRKLFSMVSWQDI CCCHHHHCCCCHHHH	28.80	-
156	Acetylation	KVIEDKPKLEKDKGK HHHCCCHHHHCCCCC	75.03	133823
159	Acetylation	EDKPKLEKDKGKAKS CCCHHHHCCCCCCCC	75.16	133819
161	Acetylation	KPKLEKDKGKAKSPK CHHHHCCCCCCCCHH	73.67	165595
163	Acetylation	KLEKDKGKAKSPKEK HHHCCCCCCCCHHHC	59.38	165599
166	Phosphorylation	KDKGKAKSPKEKKAP CCCCCCCCHHHCCCC	46.17	17081983
171	Acetylation	AKSPKEKKAPSAKPA CCCHHHCCCCCCCCC	67.62	7964645
174	Phosphorylation	PKEKKAPSAKPAKGK HHHCCCCCCCCCCCC	54.51	29396449
329	Phosphorylation	VKAADFPSDWSDGEM HHHCCCCCCCCCCHH	52.27	28509920
332	Phosphorylation	ADFPSDWSDGEMMLK CCCCCCCCCCHHHHH	40.50	28509920
404	Methylation	VPAPGKKKAQYEEPQ CCCCCCCCCCCCCCC	44.18	-
470	Phosphorylation	PPSLREPSPRADGLD CCHHCCCCCCCCCCC	23.43	29449344
735	Phosphorylation	KAQPQHESLEQTTNN HHCCCCCCCCHHCCC	34.77	30622161
750	Phosphorylation	EIKDDAVTKADSHEK CCCCCCCCCCCCCCC	23.41	29083192
754	Phosphorylation	DAVTKADSHEKKPKK CCCCCCCCCCCCCCC	38.10	29083192
880	Phosphorylation	MNEKIIRTRAELELK HCHHHHHHHHHHHHH	24.67	24719451
888	Phosphorylation	RAELELKSSANAKLT HHHHHHHHHCCCCCC	47.51	24719451
889	Phosphorylation	AELELKSSANAKLTS HHHHHHHHCCCCCCC	24.77	24719451
895	Phosphorylation	SSANAKLTSASKIFS HHCCCCCCCHHHHEE	22.88	25693802
896	Phosphorylation	SANAKLTSASKIFSI HCCCCCCCHHHHEEE	40.77	25693802
898	Phosphorylation	NAKLTSASKIFSIKE CCCCCCHHHHEEECC	26.50	25693802
902	Phosphorylation	TSASKIFSIKESKSN CCHHHHEEECCCCCC	35.90	24719451
915	Phosphorylation	SNKGISKTEISDQEK CCCCCCCCCCCHHHH	31.59	26074081
918	Phosphorylation	GISKTEISDQEKEKE CCCCCCCCHHHHHHH	27.32	26074081
957	Methylation	EERLREEKKAEKKGK HHHHHHHHHHHHHHH	53.16	-
957	"N6,N6-dimethyllysine"	EERLREEKKAEKKGK HHHHHHHHHHHHHHH	53.16	-
962	"N6,N6-dimethyllysine"	EEKKAEKKGKEAGKK HHHHHHHHHHHHHHH	67.72	-
962	Methylation	EEKKAEKKGKEAGKK HHHHHHHHHHHHHHH	67.72	-
968	Acetylation	KKGKEAGKKKGKDNA HHHHHHHHHCCCCCC	59.36	91277
969	Acetylation	KGKEAGKKKGKDNAE HHHHHHHHCCCCCCC	66.88	91279
970	Acetylation	GKEAGKKKGKDNAEK HHHHHHHCCCCCCCH	74.75	91281
987	Phosphorylation	SRSLKKKSPYKEKSK HHHHHHCCCCCCCCH	42.20	-
992	Acetylation	KKSPYKEKSKEEQVK HCCCCCCCCHHHHHH	63.78	19829915
1004	Phosphorylation	QVKIQEVTEESPHQP HHHHEECCCCCCCCC	33.03	30622161
1007	Phosphorylation	IQEVTEESPHQPEPK HEECCCCCCCCCCCC	22.81	30622161
1121	Phosphorylation	KAFSKFGSFSATLEN HHHHHHCCCEEEECC	21.11	-
1135	Phosphorylation	NGICLSISYYGSNGM CCEEEEEEEECCCCC	14.66	20058876
1139	Phosphorylation	LSISYYGSNGMAPED EEEEEECCCCCCCCC	17.68	20058876
1153	Phosphorylation	DKDPDLETILNIPSA CCCCCHHHHHCCCCC	37.75	-
1171	Phosphorylation	TVVPVIVTVPQSKAK CEEEEEEEECHHHHC	18.49	-
1175	Phosphorylation	VIVTVPQSKAKGKIK EEEEECHHHHCCCCC	28.63	-
1324	Phosphorylation	SGLICPPSEMPATPH CCCCCCHHHCCCCCC	31.50	25693802
1329	Phosphorylation	PPSEMPATPHSGDLM CHHHCCCCCCCCCHH	18.70	25693802
1332	Phosphorylation	EMPATPHSGDLMDSI HCCCCCCCCCHHHHH	34.89	25693802
1338	Phosphorylation	HSGDLMDSISQQKSE CCCCHHHHHHHHCCC	15.35	24719451
1340	Phosphorylation	GDLMDSISQQKSETI CCHHHHHHHHCCCCC	30.43	24719451
1352	Phosphorylation	ETIPSEITNTKKGKS CCCCHHHHCCCCCCC	32.55	-
1354	Phosphorylation	IPSEITNTKKGKSHK CCHHHHCCCCCCCCC	26.03	-
1433	Phosphorylation	VNGTVMTTREDKVVI CCCEEEECCCCEEEE	17.61	17081983
1548	Phosphorylation	DKDCSAVYCHESSSN CCCCCEEEEECCCCC	6.44	25693802
1552	Phosphorylation	SAVYCHESSSNIYYP CEEEEECCCCCEEEC	18.53	25693802
1553	Phosphorylation	AVYCHESSSNIYYPF EEEEECCCCCEEECC	25.15	25693802
1554	Phosphorylation	VYCHESSSNIYYPFQ EEEECCCCCEEECCH	36.20	25693802
1557	Phosphorylation	HESSSNIYYPFQKRE ECCCCCEEECCHHHH	14.88	25693802
1558	Phosphorylation	ESSSNIYYPFQKREQ CCCCCEEECCHHHHH	8.18	25693802
1616	Phosphorylation	EDDLNEKTEGYDSLS CCCCCCCCCCCCHHH	28.59	30622161
1619	Phosphorylation	LNEKTEGYDSLSSMH CCCCCCCCCHHHHHC	8.98	25693802
1621	Phosphorylation	EKTEGYDSLSSMHLE CCCCCCCHHHHHCHH	22.97	30622161
1623	Phosphorylation	TEGYDSLSSMHLEKN CCCCCHHHHHCHHHH	29.57	30622161
1624	Phosphorylation	EGYDSLSSMHLEKNH CCCCHHHHHCHHHHH	18.60	30622161
1716	Phosphorylation	IVPPNLRSRSWETFP CCCCCCCCCCCCCCC	33.56	30622161
1718	Phosphorylation	PPNLRSRSWETFPSV CCCCCCCCCCCCCCC	30.43	30622161
1721	Phosphorylation	LRSRSWETFPSVEKK CCCCCCCCCCCCCCC	34.29	30622161
1751	Phosphorylation	IESKQLVSAPGAILK ECCHHHHCCCCHHHC	37.02	-
1826	Phosphorylation	DLLKLVMSFPKMEET HHHHHHHCCCCCHHH	30.80	-
1836	Phosphorylation	KMEETTKSHVTEVAA CCHHHCHHHHHHHHH	22.54	-
1839	Phosphorylation	ETTKSHVTEVAAHLT HHCHHHHHHHHHHHH	21.22	22817900
1846	Phosphorylation	TEVAAHLTDLFKQSL HHHHHHHHHHHHHHC	22.31	22817900
1852	Phosphorylation	LTDLFKQSLATPPKC HHHHHHHHCCCCCCC	22.14	22817900
1855	Phosphorylation	LFKQSLATPPKCPPD HHHHHCCCCCCCCCC	45.47	24719451
1863	Phosphorylation	PPKCPPDTFGKDFFE CCCCCCCCCCHHHHH	39.81	29083192
1876	Phosphorylation	FEKTWRHTASSKRWK HHHHHHHHHCCHHHH	21.47	23403867
1895	Phosphorylation	KTRKEIETTQNYLMD HHHHHHHHHHHHHHH	39.07	22496350
1899	Phosphorylation	EIETTQNYLMDIKNR HHHHHHHHHHHHHHC	8.12	22817900
1936	Phosphorylation	SLSKKLPSFTKKNED HHHHHCCCCCCCCCC	56.86	24719451
1947	Phosphorylation	KNEDANETAVQDTSD CCCCCCCCCCCCCCC	31.75	25693802
1952	Phosphorylation	NETAVQDTSDLNLDF CCCCCCCCCCCCCCC	13.67	25693802
1953	Phosphorylation	ETAVQDTSDLNLDFK CCCCCCCCCCCCCCC	48.68	25693802
1969	Phosphorylation	HKVSEQKSSSVPSLP CCCCCCCCCCCCCCC	27.78	29759185
1969	O-linked_Glycosylation	HKVSEQKSSSVPSLP CCCCCCCCCCCCCCC	27.78	30379171
1970	Phosphorylation	KVSEQKSSSVPSLPK CCCCCCCCCCCCCCC	42.25	29759185
1971	Phosphorylation	VSEQKSSSVPSLPKP CCCCCCCCCCCCCCC	45.17	29759185
1974	Phosphorylation	QKSSSVPSLPKPEIS CCCCCCCCCCCCCCC	55.97	29759185
1981	Phosphorylation	SLPKPEISADKKDFT CCCCCCCCCCHHCCC	28.84	-
1988	Phosphorylation	SADKKDFTAQNQTEN CCCHHCCCCCHHHCC	37.15	29978859
1993	Phosphorylation	DFTAQNQTENLTKSP CCCCCHHHCCCCCCH	34.10	29978859
1997	Phosphorylation	QNQTENLTKSPEEAE CHHHCCCCCCHHHHH	40.85	29978859
1999	Phosphorylation	QTENLTKSPEEAESY HHCCCCCCHHHHHHC	32.10	25693802
2005	Phosphorylation	KSPEEAESYEPVKIP CCHHHHHHCCCCCCC	41.67	25693802
2006	Phosphorylation	SPEEAESYEPVKIPT CHHHHHHCCCCCCCC	18.76	25693802
2058	Phosphorylation	SVGGKVNTSSVASAA CCCCCCCHHHHHHHH	25.93	-
2059	Phosphorylation	VGGKVNTSSVASAAI CCCCCCHHHHHHHHH	20.01	22210691
2060	Phosphorylation	GGKVNTSSVASAAIN CCCCCHHHHHHHHHH	21.47	22210691
2208	Phosphorylation	VQRTSTIYSSTLGVF CCCCCEEEHHHHHHH	9.17	22817900
2209	Phosphorylation	QRTSTIYSSTLGVFM CCCCEEEHHHHHHHH	17.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPG17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPG17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPG17_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPG17_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.