SPB6_MOUSE - dbPTM
SPB6_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPB6_MOUSE
UniProt AC Q60854
Protein Name Serpin B6
Gene Name Serpinb6
Organism Mus musculus (Mouse).
Sequence Length 378
Subcellular Localization Cytoplasm .
Protein Description Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood..
Protein Sequence MDPLQEANGTFALNLLKILGEDSSKNVFLSPMSISSALAMVFMGAKGTTASQMAQALALDKCSGNGGGDVHQGFQSLLTEVNKTGTQYLLRTANRLFGDKTCDLLASFKDSCLKFYEAELEELDFQGATEESRQHINTWVAKKTEDKIKEVLSPGTVNSDTSLVLVNAIYFKGNWEKQFNKEHTREMPFKVSKNEEKPVQMMFKKSTFKMTYIGEIFTKILLLPYVSSELNMIIMLPDEHVELSTVEKEVTYEKFIEWTRLDKMDEEEVEVFLPKFKLEENYNMNDALYKLGMTDAFGGRADFSGMSSKQGLFLSKVVHKAFVEVNEEGTEAAAATAGMMTVRCMRFTPRFCADHPFLFFIHHVKTNGILFCGRFSSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDPLQEAN
-------CCHHHHCC		12.35-
23PhosphorylationLKILGEDSSKNVFLS
HHHHCCCCCCCCCCC		38.6228464351
30PhosphorylationSSKNVFLSPMSISSA
CCCCCCCCCCCHHHH		13.6926745281
33PhosphorylationNVFLSPMSISSALAM
CCCCCCCCHHHHHHH		23.7826745281
35PhosphorylationFLSPMSISSALAMVF
CCCCCCHHHHHHHHH		11.4026745281
36PhosphorylationLSPMSISSALAMVFM
CCCCCHHHHHHHHHC		26.1526745281
48PhosphorylationVFMGAKGTTASQMAQ
HHCCCCCCCHHHHHH		20.6226643407
49PhosphorylationFMGAKGTTASQMAQA
HCCCCCCCHHHHHHH		32.7426643407
51PhosphorylationGAKGTTASQMAQALA
CCCCCCHHHHHHHHH		20.5626643407
62GlutathionylationQALALDKCSGNGGGD
HHHHHHHCCCCCCCC		6.6824333276
100UbiquitinationANRLFGDKTCDLLAS
HHHHHCCCHHHHHHH		51.97-
100AcetylationANRLFGDKTCDLLAS
HHHHHCCCHHHHHHH		51.9722826441
102S-nitrosylationRLFGDKTCDLLASFK
HHHCCCHHHHHHHCH		4.2320925432
102S-nitrosocysteineRLFGDKTCDLLASFK
HHHCCCHHHHHHHCH		4.23-
107PhosphorylationKTCDLLASFKDSCLK
CHHHHHHHCHHHHHH		32.5726643407
142AcetylationHINTWVAKKTEDKIK
HHHHHHHHCCHHHHH		51.0822826441
153PhosphorylationDKIKEVLSPGTVNSD
HHHHHHCCCCCCCCC		26.8526643407
156PhosphorylationKEVLSPGTVNSDTSL
HHHCCCCCCCCCCEE		21.6526643407
159PhosphorylationLSPGTVNSDTSLVLV
CCCCCCCCCCEEEEE		37.6226643407
161PhosphorylationPGTVNSDTSLVLVNA
CCCCCCCCEEEEEEE		24.6326643407
162PhosphorylationGTVNSDTSLVLVNAI
CCCCCCCEEEEEEEE		22.8226643407
177UbiquitinationYFKGNWEKQFNKEHT
EECCCHHHHCCHHHC		52.37-
177AcetylationYFKGNWEKQFNKEHT
EECCCHHHHCCHHHC		52.3723806337
177SuccinylationYFKGNWEKQFNKEHT
EECCCHHHHCCHHHC		52.3723806337
181AcetylationNWEKQFNKEHTREMP
CHHHHCCHHHCCCCC		52.7622826441
197AcetylationKVSKNEEKPVQMMFK
ECCCCCCCCEEEEEC		44.2923806337
204AcetylationKPVQMMFKKSTFKMT
CCEEEEECCCCCCCE		28.1122826441
209AcetylationMFKKSTFKMTYIGEI
EECCCCCCCEEHHHH		30.3522826441
254AcetylationEKEVTYEKFIEWTRL
CCEEHHHHHHHHEEC		41.0322826441
277UbiquitinationEVFLPKFKLEENYNM
HHEEECCCCCCCCCC		62.20-
277AcetylationEVFLPKFKLEENYNM
HHEEECCCCCCCCCC		62.2022826441
289PhosphorylationYNMNDALYKLGMTDA
CCCCHHHHHCCCCCC		13.0922817900
290AcetylationNMNDALYKLGMTDAF
CCCHHHHHCCCCCCC		39.1422826441
309AcetylationDFSGMSSKQGLFLSK
CCCCCCCCCCCHHHH		40.8722826441
316AcetylationKQGLFLSKVVHKAFV
CCCCHHHHHHHHHHH		50.8822826441
320AcetylationFLSKVVHKAFVEVNE
HHHHHHHHHHHEECC		31.7322826441
352GlutathionylationMRFTPRFCADHPFLF
HHCCHHHHCCCCEEE		4.6124333276
372S-nitrosocysteineKTNGILFCGRFSSP-
EECCEEEEEECCCC-		3.24-
372S-nitrosylationKTNGILFCGRFSSP-
EECCEEEEEECCCC-		3.2421278135
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPB6_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPB6_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPB6_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SPB6_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPB6_MOUSE

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Related Literatures of Post-Translational Modification

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