dbPTM

SPB5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPB5_MOUSE
UniProt AC	P70124
Protein Name	Serpin B5
Gene Name	Serpinb5
Organism	Mus musculus (Mouse).
Sequence Length	375
Subcellular Localization	Secreted, extracellular space.
Protein Description	Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity)..
Protein Sequence	MDALRLANSAFAVDLFKQLCERDPAGNILFSPICLSTSLSLAQVGTKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLVKRLYIDKSLNPSTEFISSTKRPYAKELETVDFKDKLEETKGQINSSIKELTDGHFEDILSENSISDQTKILVVNAAYFVGKWMKKFPESETKECPFRISKTDTKPVQMMNLEATFCLGNIDDISCKIIELPFQNKHLSMLIVLPKDVEDESTGLEKIEQQLNPETLLQWTNPSTMANAKVKLSLPKFKVEKMIDPKASLESLGLKSLFNESTSDFSGMSETKGVSLSNVIHRVCLEITEDGGESIEVPGSRILQHKDEFNADHPFIYIIRHNKTRNIIFFGKFCSP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	NKLSSFYSLKLVKRL HHHHHHHHHHHHHHH	19.60	-
133	N-linked_Glycosylation	EETKGQINSSIKELT HHHHHCCCHHHHHHH	23.09	-
287	Phosphorylation	KMIDPKASLESLGLK ECCCCCHHHHHHCHH	38.50	25338131
290	Phosphorylation	DPKASLESLGLKSLF CCCHHHHHHCHHHHH	32.79	25338131
298	N-linked_Glycosylation	LGLKSLFNESTSDFS HCHHHHHCCCCCCCC	47.83	-
361	N-linked_Glycosylation	FIYIIRHNKTRNIIF EEEEEECCCCCEEEE	37.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPB5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPB5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPB5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SPB5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPB5_MOUSE

Related Literatures of Post-Translational Modification