| UniProt ID | SPB10_HUMAN | |
|---|---|---|
| UniProt AC | P48595 | |
| Protein Name | Serpin B10 | |
| Gene Name | SERPINB10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 397 | |
| Subcellular Localization | Nucleus. Cytoplasm. Mostly found in the nucleus. | |
| Protein Description | Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.. | |
| Protein Sequence | MDSLATSINQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVKCDPESEKKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFHNKYLEDMKTYFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWEHQFLVQNTTEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDINGLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSGMSSARNLFLSNVFHKAFVEINEQGTEAAAGSGSEIDIRIRVPSIEFNANHPFLFFIRHNKTNTILFYGRLCSP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Phosphorylation | LSKKLAESAQGKNIF HHHHHHHHHCCCCCE | 21.93 | 24260401 | |
| 156 | Phosphorylation | QIRKDINSWVERQTE HHHHHHHHHHHHHCC | 32.60 | 24850871 | |
| 299 | Phosphorylation | PKFKLEDSYDLKSTL CCCCCCCCCCHHHHH | 15.92 | 30576142 | |
| 307 | Phosphorylation | YDLKSTLSSMGMSDA CCHHHHHHHCCCHHH | 20.54 | 17287340 | |
| 312 | Phosphorylation | TLSSMGMSDAFSQSK HHHHCCCHHHHHCCC | 21.76 | 30576142 | |
| 316 | Phosphorylation | MGMSDAFSQSKADFS CCCHHHHHCCCCCCC | 34.95 | 30576142 | |
| 318 | Phosphorylation | MSDAFSQSKADFSGM CHHHHHCCCCCCCCC | 28.72 | 30576142 | |
| 327 | Phosphorylation | ADFSGMSSARNLFLS CCCCCCHHHHHHHHH | 23.50 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPB10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPB10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPB10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SPB10_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND MASSSPECTROMETRY. | |
